MAD COW DISEASE typical vs atypical terminology

Sunday, March 16, 2008

MAD COW DISEASE terminology UK c-BSE (typical), atypical BSE H or L, and or Italian L-BASE

Greetings,

I thought i might try and sort things out about this a bit. Some folks seem to be a bit confused,(confusious included has been confused a time or two to be sure). but i think some clarification needs to be done. you can interpret it the way you want. i have my opinions on why i interpret the science one way, you may have yours. here goes ;

WE first heard of the atypical called BASE Bovine Amyloidotic Spongiform Encephalopathy (Italy), and it was said then that the molecular signature of this previously undescribed bovine PrPSc was similar to that encountered in a distinct subtype of sporadic Creutzfeldt-Jakob disease. The Italian BASE Bovine Amyloidotic Spongiform Encephalopathy termed that due to the 'amyloid plaques'.

THIS is where i start to have problems with the term. if you will recall, the first ten nvCJD in young adolescents, 'amyloid plaques' were used then to differentiate between the sporadic CJDs and nvCJD, UNTIL the 'amyloid plaques' stared showing up in some sporadic CJDs. now (10%) amyloid deposits, called prion protein (PrP) amyloid plaques, may be observed in sporadic CJD.

ALSO, with the BASE, you will find that some want to hypothesize that the BASE is just BSE in older cattle.

well, if that was the case, then would not sporadic CJD be just nvCJD in old people?

ALSO, it was said that nvCJD was only in the young. this too was part of a diagnostic criteria to differentiate between the nvCJD and sporadic CJDs, until sCJD started showing up in young adolescents.

ALSO, it was said that only the nvCJD have long incubation period, this too was part of diagnostic criteria to differentiate between the nvCJD and sporadic CJDs, until the long incubation started showing up in some sporadic CJDs.

ALSO, it was said that on the nvCJD victims had psychological mental symptoms, not the sporadic CJDs, that too until the psychological and mental symptoms started showing up in some of the sporadic CJDs.

FOR these reasons, I cannot accept that the difference in bands and mass (heavier or lighter), are the meaning of another different strain differentiating between UK c-BSE (typical), atypical BSE H or L, and or Italian L-BASE.

I think i might be partly to blame for the confusion, because sometimes i will use BASE, and sometimes i will use atypical BSE, h or l. same with the nvCJD, i still catch myself using that term, as opposed to the newest terminology of vCJD.

kind regards,
terry

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Sunday, March 16, 2008

MAD COW DISEASE terminology UK c-BSE (typical), atypical BSE H or L, and or Italian L-BASE

http://bse-atypical.blogspot.com/2008/03/mad-cow-disease-terminology-uk-c-bse.html


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