QUESTIONS AND ANSWERS HALLMARK/WESTLAND MEAT PACKING CO.
March 6, 2008
Consumer Concerns
Q. My child/school recently consumed Hallmark/Westland products. What is the risk to children's health?
A. Extremely remote. USDA's Agricultural Marketing Service (AMS) has every production lot of ground beef tested by independent laboratories for certain pathogens and indicator organisms. Those lots that have positive findings of E. coli 0157:H7 or Salmonella are prohibited from Federal food and nutrition programs and USDA's Food Safety and Inspection Service is notified. AMS had only one positive test result at Hallmark/Westland and this product was removed from the AMS supply chain and not delivered to any Federal food and nutrition program.
USDA is confident in the safety of the food supply. Human and animal health is protected by a system of interlocking safeguards, which also include the removal of specified risk materials—those tissues that studies have demonstrated could contain the bovine spongiform encephalopathy (BSE) agent in infected cattle—from the human food chain, along with the U.S. Food and Drug Administration's 1997 ruminant to ruminant feed ban.
The cattle at the Hallmark/Westland Meat Packing Company passed ante-mortem inspection before slaughter. While the federal government has multiple regulations regarding BSE in place, the prevalence of the disease in the United States is extremely low. Since June 1, 2004, APHIS has sampled more than 759,000 animals and, to date, only 2 animals have tested positive for BSE under the program.
Q. How can I find out whether my school or school district served any Hallmark/Westland products to my children?
A. State Distributing Agencies that handle commodities purchased by USDA have records on where Hallmark/Westland products were delivered within the State. Contact information is available at www.usda.gov/actions.
http://www.usda.gov/wps/portal/usdahome?contentidonly=true&contentid=Consumer_Concerns.xml
Release No. 0048.08 Contact: Office of Communications (202)720-4623
QUESTIONS AND ANSWERS HALLMARK/WESTLAND MEAT PACKING CO.
Updated: March 07, 2008
USDA Actions
Recall Information
Bovine Spongiform Encephalopathy Control Measures
Consumer Concerns
Humane Handling
International Trade
http://www.usda.gov/wps/portal/usdahome?contentidonly=true&contentid=2008/02/0048.xml
USDA ET AL PROTECTING THEIR OWN $$$
Congress Wants More Info on Beef Recall By ERICA WERNER – 1 day ago
WASHINGTON (AP) — Lawmakers demanded Thursday that the Agriculture Department disclose which retailers sold meat that was recently recalled in the nation's largest beef recall.
Richard Raymond, the department's undersecretary for food safety, told angry Democrats on the House Appropriations agriculture subcommittee that the information is proprietary and can't be made public.
Some 10,000 consignees — from producers to retail establishments — received the potentially tainted meat from the Westland/Hallmark Meat Co. in Chino, Calif., Raymond said. But he said he couldn't reveal which ones, and most of the meat had already been eaten because the recall stretched back two years.
Westland/Hallmark recalled 143 million pounds of beef last month after the Humane Society of the United States released undercover video of cattle being abused and cows that couldn't walk being prodded to slaughter.
Democratic lawmakers said it was unacceptable for the public not to know where the meat went. So-called "downer" cattle pose a higher risk of E. coli, salmonella and other illnesses.
"This is not proprietary information. This is information that is directly engaged in the health and safety of the American people, which we have a responsibility, along with you, to protect," said Rep. Maurice Hinchey, D-N.Y.
Hinchey demanded a list of the retailers by next week. Raymond said he'd consult with Agriculture Department attorneys on whether he could comply.
The Bush administration has opposed publicizing retailers' names in meat recalls, but the Agriculture Department's Food Safety and Inspection Service proposed a rule change two years ago that would allow such disclosure.
The rule still hasn't been finalized. Raymond said it was in final review at the Agriculture Department before being sent to the White House budget office.
"It is in the final stages of clearance," he said.
Democrats contended the Bush administration was delaying the rule under pressure from industry.
California, unique among states, has its own law allowing for disclosure of the names of the retailers where recalled beef was available. The law took effect just last July. A 120-page list of retailers is posted on the California Department of Public Health Web site at http://dhs.ca.gov/ and is still being updated, California officials said.
The rules on public disclosure are different for meat that went into federal programs, which more than 50 million pounds of the Westland/Hallmark meat did, mostly school lunches. Individual state distributing agencies have their own approaches for disclosing information about the recalled meat.
Contacts for state distributing agencies are at
http://www.fns.usda.gov/fdd/contacts/sdacontacts.htm.
To date, of the 50.3 million pounds of Westland/Hallmark product in the federal food and nutrition programs, 31 million pounds have been consumed, 13.9 million pounds are on hold, and 6.5 million pounds are being traced, according to USDA.
http://ap.google.com/article/ALeqM5gjgIDJ5Z2xZSLp6TUi-kRcCFXmPgD8V855IG0
Animal Mortality Figures
The U.S. Department of Agriculture (USDA) estimates 1.7103 million cattle and 2.3656 million calves died prior to slaughter in 2002, for a total of just under 4.1 million deaths.
snip...
Cattle, however, with their heavier body weights, comprise approximately 67 percent of the total weight of all mammalian livestock mortalities. In 2002, the total weight for cattle was 2.7 billion pounds. Beef cattle account for the largest proportion of farm, ranch, and feedlot mortality, in respect to weight.
snip...
Focus on Non-Ambulatory Cattle
Non-ambulatory cattle have been estimated by USDA to be approximately 200,000 head per year based on a 1999 American Association of Bovine Practitioners survey.(2) It is proposed that this estimate understates the condition by not fully accounting for feedlot cattle of younger ages commonly affected with metabolic and or respiratory disorders that often present neurological-like clinical symptoms and thus described as non-ambulatory. It is impossible to give accurate figures on incidence because of variations in nomenclature and the accuracy of diagnosis. Because it is a syndrome until an accurate diagnosis is confirmed, the exact incidence is speculative.
http://www.rendermagazine.com/October2004/TechTopics.html
MARCH 2002
Livestock Mortalities:
Methods of Disposal and Their
Potential Costs
USDA/National Agricultural Statistics Service (NASS) estimates that in the year 2000,
approximately 4.1 million cattle died before they could be sent to slaughter (Table 2). Of these, 2.4 million were calves (under 500 lbs), with the balance of 1.7 million over 6 months of age (or, as reported, in excess of 500 lbs). ....END...TSS
NASS
Non-Ambulatory
Cattle and Calves
Released May 5, 2005, by the National Agricultural Statistics Service (NASS), Agricultural Statistics Board, U.S. Department
of Agriculture. For information on Non-ambulatory Cattle and Calves call Mike Miller at 720-3040, office hours 7:30 a.m. to
4:30 p.m. ET.
Cattle and Calves: Non-Ambulatory Number,
by Region and United States, 2003-2004
ALL NON-AMBULATORY CATTLE 2003 = 465,000
ALL NON-AMBULATORY CATTLE 2004 = 450,000
SNIP...END...TSS
Non-Ambulatory
Cattle and Calves
Released May 5, 2005, by the National Agricultural Statistics Service (NASS), Agricultural Statistics Board, U.S. Department
of Agriculture. For information on Non-ambulatory Cattle and Calves call Mike Miller at 720-3040, office hours 7:30 a.m. to
4:30 p.m. ET.
Non-Ambulatory Cattle and Calves
Non-ambulatory cattle and calves in the United States totaled 465,000 head during 2003 and
450,000 head during 2004. The number of non-ambulatory cattle 500 pounds or greater totaled
280,000 head in 2003 and 270,000 head in 2004. The number of calves under 500 pounds reported
as non-ambulatory totaled 185,000 head in 2003 and 180,000 head in 2004. ...SNIP...END
=======================================================
USDA states ;
>>>Human and animal health is protected by a system of interlocking safeguards, which also include the removal of specified risk materials—those tissues that studies have demonstrated could contain the bovine spongiform encephalopathy (BSE) agent in infected cattle—from the human food chain, along with the U.S. Food and Drug Administration's 1997 ruminant to ruminant feed ban. <<<
href="http://www.fda.gov/Safety/Recalls/EnforcementReports/2007/ucm120446.htm">http://www.fda.gov/Safety/Recalls/EnforcementReports/2007/ucm120446.htm
Subject: MAD COW FEED RECALL USA SEPT 6, 2006 1961.72 TONS IN COMMERCE AL, TN, AND WV Date: September 6, 2006 at 7:58 am PST PRODUCT a) EVSRC Custom dairy feed, Recall # V-130-6; b)
snip...
PLEASE SEE SOME OF THE REST OF THE MAD COW FEED BAN SRM VIOLATIONS ;
http://madcowspontaneousnot.blogspot.com/2008/02/specified-risk-materials-srm.html
>>>USDA STATES ; While the federal government has multiple regulations regarding BSE in place, the prevalence of the disease in the United States is extremely low. Since June 1, 2004, APHIS has sampled more than 759,000 animals and, to date, only 2 animals have tested positive for BSE under the program. <<<>400,000 tests in 2005 (Figure 4). Neither of the 2 more recently indigenously infected older animals with nonspecific clinical features would have been detected without such testing, and neither would have been identified as atypical without confirmatory Western blots. Despite these facts, surveillance has now been decimated to 40,000 annual tests (USDA news release no. 0255.06, July 20, 2006) and invites the accusation that the United States will never know the true status of its involvement with BSE.
http://www.cdc.gov/ncidod/EID/vol12no12/06-0965.htm
PAUL BROWN COMMENT TO ME ON THIS ISSUE
Tuesday, September 12, 2006 11:10 AM
"Actually, Terry, I have been critical of the USDA handling of the mad cow issue for some years, and with Linda Detwiler and others sent lengthy detailed critiques and recommendations to both the USDA and the Canadian Food Agency."
http://lists.iatp.org/listarchive/archive.cfm?listID=147&startrow=1081
CDC DR. PAUL BROWN TSE EXPERT COMMENTS 2006
The U.S. Department of Agriculture was quick to assure the public earlier this week that the third case of mad cow disease did not pose a risk to them, but what federal officials have not acknowledged is that this latest case indicates the deadly disease has been circulating in U.S. herds for at least a decade.
The second case, which was detected last year in a Texas cow and which USDA officials were reluctant to verify, was approximately 12 years old.
These two cases (the latest was detected in an Alabama cow) present a picture of the disease having been here for 10 years or so, since it is thought that cows usually contract the disease from contaminated feed they consume as calves. The concern is that humans can contract a fatal, incurable, brain-wasting illness from consuming beef products contaminated with the mad cow pathogen.
"The fact the Texas cow showed up fairly clearly implied the existence of other undetected cases," Dr. Paul Brown, former medical director of the National Institutes of Health's Laboratory for Central Nervous System Studies and an expert on mad cow-like diseases, told United Press International. "The question was, 'How many?' and we still can't answer that."
Brown, who is preparing a scientific paper based on the latest two mad cow cases to estimate the maximum number of infected cows that occurred in the United States, said he has "absolutely no confidence in USDA tests before one year ago" because of the agency's reluctance to retest the Texas cow that initially tested positive.
USDA officials finally retested the cow and confirmed it was infected seven months later, but only at the insistence of the agency's inspector general.
"Everything they did on the Texas cow makes everything USDA did before 2005 suspect," Brown said. ...snip...end
http://www.upi.com/ConsumerHealthDaily/view.php?StoryID=20060315-055557-1284r
CDC - Bovine Spongiform Encephalopathy and Variant Creutzfeldt ... Dr. Paul Brown is Senior Research Scientist in the Laboratory of Central Nervous System ... Address for correspondence: Paul Brown, Building 36, Room 4A-05, ...
http://www.cdc.gov/ncidod/eid/vol7no1/brown.htm
Geographical BSE Risk (GBR) assessments covering 2000-2006
Date : 01.08.2006
http://www.efsa.europa.eu/EFSA/Scientific_Document/GBR_assessments_table_Overview_assessed_countries_2002-2006.pdf
Audit Report
Animal and Plant Health Inspection Service
Bovine Spongiform Encephalopathy (BSE) Surveillance Program - Phase II
and
Food Safety and Inspection Service
Controls Over BSE Sampling, Specified Risk Materials, and Advanced Meat Recovery Products - Phase III
Report No. 50601-10-KC January 2006
Finding 2 Inherent Challenges in Identifying and Testing High-Risk Cattle Still Remain
Our prior report identified a number of inherent problems in identifying and testing high-risk cattle. We reported that the challenges in identifying the universe of high-risk cattle, as well as the need to design procedures to obtain an appropriate representation of samples, was critical to the success of the BSE surveillance program. The surveillance program was designed to target nonambulatory cattle, cattle showing signs of CNS disease (including cattle testing negative for rabies), cattle showing signs not inconsistent with BSE, and dead cattle. Although APHIS designed procedures to ensure FSIS condemned cattle were sampled and made a concerted effort for outreach to obtain targeted samples, industry practices not considered in the design of the surveillance program reduced assurance that targeted animals were tested for BSE.
USDA/OIG-A/50601-10-KC Page 27
observe these animals ante mortem when possible to assure the animals from the target population are ultimately sampled and the clinical signs evaluated.
snip...
http://www.usda.gov/oig/webdocs/50601-10-KC.pdf
GAO-05-51 October 2004 FOOD SAFETY
over 500 customers receiving potentially BSE contaminated beef .....
* GAO-05-51 October 2004 FOOD SAFETY (over 500 customers receiving potentially BSE contaminated beef) - TSS 10/20/04
October 2004 FOOD SAFETY USDA and FDA Need to Better Ensure Prompt and Complete Recalls of Potentially Unsafe Food
snip...
REPORTS
1. Food Safety: USDA and FDA Need to Better Ensure Prompt and Complete Recalls of Potentially Unsafe Food. GAO-05-51, October 7.tss
http://www.gao.gov/new.items/d0551.pdf
Highlights -
http://www.gao.gov/highlights/d0551high.pdf
3. Mad Cow Disease: FDA's Management of the Feed Ban Has Improved, but Oversight Weaknesses Continue to Limit Program Effectiveness. GAO-05-101, Feb. 25.
www.gao.gov/cgi-bin/getrpt?GAO-05-101
Highlights -
www.gao.gov/highlights/d05101high.pdf
SADLY, DEC 2005 SHOWS THAT WE STILL HAVE A SERIOUS PROBLEM WITH BSE/TSE MAD COW DISEASE FEED
GAO
GAO-06-157R FDA Feed Testing Program
October 11, 2005
SNIP...FULL TEXT 29 PAGES ;
http://www.gao.gov/new.items/d06157r.pdf
Mad Cow Disease: An Evaluation of a Small Feed Testing Program FDA Implemented in 2003 With Recommendations for Making the Program a Better Oversight Tool. GAO-06-157R, October 11
http://www.gao.gov/cgi-bin/getrpt?GAO-06-157R
Wednesday, February 27, 2008
BEEF RECALL NATIONWIDE - SCHOOL LUNCH PROGRAM UPDATE
http://downercattle.blogspot.com/2008/02/beef-recall-nationwide-school-lunch.html
Thursday, March 6, 2008
California lists possible recipients of recalled non-ambulatory 'DOWNER' (high potential for TSE) Hallmark beef
http://downercattle.blogspot.com/2008/03/california-lists-possible-recipients-of.html
Thursday, March 6, 2008
House committee subpoenas Hallmark/Westland CEO - i call for an investigation of the investigators
http://downercattle.blogspot.com/2008/03/house-committee-subpoenas.html
Thursday, March 6, 2008
USDA to Hallmark: We want our plaque back
Legal/Regulatory News
http://downercattle.blogspot.com/2008/03/usda-to-hallmark-we-want-our-plaque.html
Thursday, March 6, 2008
To the hard working employees of USDA and their untiring efforts to protect our childrens food supply
http://downercattle.blogspot.com/2008/03/to-hard-working-employees-of-usda-and.html
BEEF RECALL - USA (05) ********************** A ProMED-mail post
ProMED-mail is a program of the International Society for Infectious Diseases
http://www.promedmail.org/pls/otn/f?p=2400:1001:3581618507331539::NO::F2400_P1001_BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,71607
THE USDA knows PERFECTLY WELL that no one would get sick right off the bat from mad cow disease. Every parent out there should be demanding answers, not these same lies. THE USDA should follow every single child that consumed any of these products for the rest of there lives. there is no way out of it now. the product is gone, consumed, and these kids, the elderly, and most everybody in between have been exposed. non-ambulatory i.e. DOWNERS are the most likely to have a Transmissible Spongiform Encephalopathy. WE know it's here, we know why the USDA et al shut down the testing, they did not want to document any more. ...TSS
Science 23 November 2001: Vol. 294. no. 5547, pp. 1726 - 1728 DOI: 10.1126/science.1066838
Reports
Estimation of Epidemic Size and Incubation Time Based on Age Characteristics of vCJD in the United Kingdom
Alain-Jacques Valleron,1 Pierre-Yves Boelle,1 Robert Will,2 Jean-Yves Cesbron3
SNIP...
The distribution of the vCJD incubation period that best fits the data within the framework of our model has a mean of 16.7 years, with a standard deviation of 2.6 years. The 95% upper percentile of this distribution is 21.4 years. The 95% confidence interval (CI) of the estimates of the mean and standard deviation is relatively narrow: The 95% CI for the estimate of the mean incubation period is 12.4 to 23.2 years, and the 95% CI of the standard deviation is 0.9 to 8 years (10). The decrease in susceptibility to infection in exposed subjects older than 15 years, as estimated from the parameter , was found to be very sharp: 16% per year of age (CI: 12 to 23%). This means that, under the best fitting hypothesis, an individual aged 20 years in 1981 had 55% less risk of becoming infected than a child aged 15 years (99.9% for an individual aged 70).
http://www.sciencemag.org/
NOW, the price of poker in the USA may be shorter, due to the fact the strain of mad cow disease in the USA is more virulent to humans, thus, the incubation period, for the same titre log of infectivity, via same route and source, might be faster. ...TSS
Communicated by: Terry S. Singeltary Sr.
[In submitting these data, Terry S. Singeltary Sr. draws attention to the steady increase in the "type unknown" category, which, according to their definition, comprises cases in which vCJD could be excluded. The total of 26 cases for the current year (2007) is disturbing, possibly symptomatic of the circulation of novel agents. Characterization of these agents should be given a high priority. - Mod.CP]
[see also:
snip...
************************************************************ Become a ProMED-mail Premium Subscriber at
************************************************************ Visit ProMED-mail's web site at .
http://pro-med.blogspot.com/2007/11/proahedr-prion-disease-update-2007-07.html
SEE STEADY INCREASE IN SPORADIC CJD IN THE USA FROM 1997 TO 2006. SPORADIC CJD CASES TRIPLED, with phenotype of 'UNKNOWN' strain growing. ...
http://www.cjdsurveillance.com/resources-casereport.html
There is a growing number of human CJD cases, and they were presented last week in San Francisco by Luigi Gambatti(?) from his CJD surveillance collection.
He estimates that it may be up to 14 or 15 persons which display selectively SPRPSC and practically no detected RPRPSC proteins.
http://www.fda.gov/ohrms/dockets/ac/06/transcripts/1006-4240t1.htm
http://www.fda.gov/ohrms/dockets/ac/06/transcripts/2006-4240t1.pdf
PLEASE SEE !
P02.35 Molecular Features of the Protease-resistant Prion Protein (PrPres) in H- type BSE
Biacabe, A-G1; Jacobs, JG2; Gavier-Widén, D3; Vulin, J1; Langeveld, JPM2; Baron, TGM1 1AFSSA, France; 2CIDC-Lelystad, Netherlands; 3SVA, Sweden
Western blot analyses of PrPres accumulating in the brain of BSE- infected cattle have demonstrated 3 different molecular phenotypes regarding to the apparent molecular masses and glycoform ratios of PrPres bands. We initially described isolates (H-type BSE) essentially characterized by higher PrPres molecular mass and decreased levels of the diglycosylated PrPres band, in contrast to the classical type of BSE. This type is also distinct from another BSE phenotype named L-type BSE, or also BASE (for Bovine Amyloid Spongiform Encephalopathy), mainly characterized by a low representation of the diglycosylated PrPres band as well as a lower PrPres molecular mass. Retrospective molecular studies in France of all available BSE cases older than 8 years old and of part of the other cases identified since the beginning of the exhaustive surveillance of the disease in 20001 allowed to identify 7 H- type BSE cases, among 594 BSE cases that could be classified as classical, L- or H-type BSE. By Western blot analysis of H-type PrPres, we described a remarkable specific feature with antibodies raised against the C-terminal region of PrP that demonstrated the existence of a more C-terminal cleaved form of PrPres (named PrPres#2 ), in addition to the usual PrPres form (PrPres #1). In the unglycosylated form, PrPres #2 migrates at about 14 kDa, compared to 20 kDa for PrPres #1. The proportion of the PrPres#2 in cattle seems to by higher compared to the PrPres#1. Furthermore another PK–resistant fragment at about 7 kDa was detected by some more N-terminal antibodies and presumed to be the result of cleavages of both N- and C- terminal parts of PrP. These singular features were maintained after transmission of the disease to C57Bl/6 mice. The identification of these two additional PrPres fragments (PrPres #2 and 7kDa band) *** reminds features reported respectively in sporadic Creutzfeldt-Jakob disease and in Gerstmann-Sträussler-Scheinker (GSS) syndrome in humans.
FC5.5.1 BASE Transmitted to Primates and MV2 sCJD Subtype Share PrP27-30 and PrPSc C-terminal Truncated Fragments
Zanusso, G1; Commoy, E2; Fasoli, E3; Fiorini, M3; Lescoutra, N4; Ruchoux, MM4; Casalone, C5; Caramelli, M5; Ferrari, S3; Lasmezas, C6; Deslys, J-P4; Monaco, S3 1University of Verona, of Neurological and Visual Sciences, Italy; 2CEA, IMETI/SEPIA, France; 3University of Verona, Neurological and Visual Sciences, Italy; 4IMETI/SEPIA, France; 5IZSPLVA, Italy; 6The Scripps Research Insitute, USA
The etiology of sporadic Creutzfeldt-Jakob disease (sCJD), the most frequent human prion disease, remains still unknown. The marked disease phenotype heterogeneity observed in sCJD is thought to be influenced by the type of proteinase K- resistant prion protein, or PrPSc (type 1 or type 2 according to the electrophoretic mobility of the unglycosylated backbone), and by the host polymorphic Methionine/Valine (M/V) codon 129 of the PRNP. By using a two-dimensional gel electrophoresis (2D-PAGE) and imunoblotting we previously showed that in sCJD, in addition to the PrPSc type, distinct PrPSc C-terminal truncated fragments (CTFs) correlated with different sCJD subtypes. Based on the combination of CTFs and PrPSc type, we distinguished three PrPSc patterns: (i) the first was observed in sCJD with PrPSc type 1 of all genotypes,;
(ii) the second was found in M/M-2 (cortical form); (iii) the third in amyloidogenic M/V- 2 and V/V-2 subtypes (Zanusso et al., JBC 2004) . Recently, we showed that sCJD subtype M/V-2 shared molecular and pathological features with an atypical form of BSE, named BASE, thus suggesting a potential link between the two conditions. This connection was further confirmed after 2D-PAGE analysis, which showed an identical PrPSc signature, including the biochemical pattern of CTFs. To pursue this issue, we obtained brain homogenates from Cynomolgus macaques intracerebrally inoculated with brain homogenates from BASE. Samples were separated by using a twodimensional electrophoresis (2D-PAGE) followed by immunoblotting. We here show that the PrPSc pattern obtained in infected primates is identical to BASE and sCJD MV-2 subtype. *** These data strongly support the link, or at least a common ancestry, between a sCJD subtype and BASE.
This work was supported by Neuroprion (FOOD-CT-2004-506579)
************************************************** *****
USA MAD COW CASES IN ALABAMA AND TEXAS
***PLEASE NOTE***
USA BASE CASE, (ATYPICAL BSE), AND OR TSE (whatever they are calling it today), please note that both the ALABAMA COW, AND THE TEXAS COW,both were ''H-TYPE'', personal communication Detwiler et al Wednesday, August 22, 2007 11:52 PM. ...TSS
2009 UPDATE ON ALABAMA AND TEXAS MAD COWS 2005 and 2006
http://bse-atypical.blogspot.com/2006/08/bse-atypical-texas-and-alabama-update.html
Wednesday, November 18, 2009
R-CALF: 40 Groups Disagree With USDA's Latest BSE Court Submission
http://bse-atypical.blogspot.com/2009/11/r-calf-40-groups-disagree-with-usdas.html
**************************************************
FC5.5.2 Transmission of Italian BSE and BASE Isolates in Cattle Results into a Typical BSE Phenotype and a Muscle Wasting Disease
Zanusso, G1; Lombardi, G2; Casalone, C3; D’Angelo, A4; Gelmetti, D2; Torcoli, G2; Barbieri, I2; Corona, C3; Fasoli, E1; Farinazzo, A1; Fiorini, M1; Gelati, M1; Iulini, B3; Tagliavini, F5; Ferrari, S1; Monaco, S1; Caramelli, M3; Capucci, L2 1University of Verona, Neurological and Visual Sciences, Italy; 2IZSLER, Italy; 3IZSPLVA, Italy; 4University of Turin, Animal Pathology, Italy; 5Isituto Carlo Besta, Italy
The clinical phenotype of bovine spongiform encephalopathy has been extensively reported in early accounts of the disorder. Following the introduction of statutory active surveillance, almost all BSE cases have been diagnosed on a pathological/molecular basis, in a pre-symptomatic clinical stage. In recent years, the active surveillance system has uncovered atypical BSE cases, which are characterized by distinct conformers of the PrPSc, named high-type (BSE-H) and low-type (BSE-L), whose clinicopathological phenotypes remain unknown. We recently reported two Italian atypical cases with a PrPSc type similar to BSE-L, pathologically characterized by PrP amyloid plaques. Experimental transmission to TgBov mice has recently disclosed that BASE is caused by a distinct prion strain which is extremely virulent. A major limitation of transmission studies to mice is the lack of reliable information on clinical phenotype of BASE in its natural host. In the present study, we experimentally infected Fresian/Holstein and Alpine/Brown cattle with Italian BSE and BASE isolates by i.c. route. BASE infected cattle showed survival times significantly shorter than BSE, a finding more readily evident in Fresian/Holstein, and in keeping with previous observations in TgBov mice. Clinically, BSE-infected cattle developed a disease phenotype highly comparable with that described in field BSE cases and in experimentally challenged cattle. On the contrary, BASE-inoculated cattle developed an amyotrophic disorder accompanied by mental dullness. The molecular and neuropathological profiles, including PrP deposition pattern, closely matched those observed in the original cases. This study further confirms that BASE is caused by a distinct prion isolate and discloses a novel disease phenotype in cattle, closely resembling the phenotype previous reported in scrapie-inoculated cattle *** and in some subtypes of inherited and sporadic Creutzfeldt-Jakob disease.
Oral Abstracts 14
snip...
P04.27
Experimental BSE Infection of Non-human Primates: Efficacy of the Oral Route
Holznagel, E1; Yutzy, B1; Deslys, J-P2; Lasmézas, C2; Pocchiari, M3; Ingrosso, L3; Bierke, P4; Schulz-Schaeffer, W5; Motzkus, D6; Hunsmann, G6; Löwer, J1 1Paul-Ehrlich-Institut, Germany; 2Commissariat à l´Energie Atomique, France; 3Instituto Superiore di Sanità, Italy; 4Swedish Institute for Infectious Disease control, Sweden; 5Georg August University, Germany; 6German Primate Center, Germany
Background:
In 2001, a study was initiated in primates to assess the risk for humans to contract BSE through contaminated food. For this purpose, BSE brain was titrated in cynomolgus monkeys.
Aims:
The primary objective is the determination of the minimal infectious dose (MID50) for oral exposure to BSE in a simian model, and, by in doing this, to assess the risk for humans. Secondly, we aimed at examining the course of the disease to identify possible biomarkers.
Methods:
Groups with six monkeys each were orally dosed with lowering amounts of BSE brain: 16g, 5g, 0.5g, 0.05g, and 0.005g. In a second titration study, animals were intracerebrally (i.c.) dosed (50, 5, 0.5, 0.05, and 0.005 mg).
Results:
In an ongoing study, a considerable number of high-dosed macaques already developed simian vCJD upon oral or intracerebral exposure or are at the onset of the clinical phase. However, there are differences in the clinical course between orally and intracerebrally infected animals that may influence the detection of biomarkers.
Conclusions:
Simian vCJD can be easily triggered in cynomolgus monkeys on the oral route using less than 5 g BSE brain homogenate. The difference in the incubation period between 5 g oral and 5 mg i.c. is only 1 year (5 years versus 4 years). However, there are rapid progressors among orally dosed monkeys that develop simian v CJD as fast as intracerebrally inoculated animals.
The work referenced was performed in partial fulfilment of the study “BSE in primates“ supported by the EU (QLK1-2002-01096).
http://www.prion2007.com/pdf/Prion%20Book%20of%20Abstracts.pdf
Subject: Aspects of the Cerebellar Neuropathology in Nor98
Date: September 26, 2007 at 4:06 pm PST
P03.141
Aspects of the Cerebellar Neuropathology in Nor98
Gavier-Widén, D1; Benestad, SL2; Ottander, L1; Westergren, E1 1National Veterinary Insitute, Sweden; 2National Veterinary Institute, Norway
Nor98 is a prion disease of old sheep and goats. This atypical form of scrapie was first described in Norway in 1998. Several features of Nor98 were shown to be different from classical scrapie including the distribution of disease associated prion protein (PrPd) accumulation in the brain. The cerebellum is generally the most affected brain area in Nor98. The study here presented aimed at adding information on the neuropathology in the cerebellum of Nor98 naturally affected sheep of various genotypes in Sweden and Norway. A panel of histochemical and immunohistochemical (IHC) stainings such as IHC for PrPd, synaptophysin, glial fibrillary acidic protein, amyloid, and cell markers for phagocytic cells were conducted. The type of histological lesions and tissue reactions were evaluated. The types of PrPd deposition were characterized. The cerebellar cortex was regularly affected, even though there was a variation in the severity of the lesions from case to case. Neuropil vacuolation was more marked in the molecular layer, but affected also the granular cell layer. There was a loss of granule cells. Punctate deposition of PrPd was characteristic. It was morphologically and in distribution identical with that of synaptophysin, suggesting that PrPd accumulates in the synaptic structures. PrPd was also observed in the granule cell layer and in the white matter. *** The pathology features of Nor98 in the cerebellum of the affected sheep showed similarities with those of sporadic Creutzfeldt-Jakob disease in humans.
http://www.prion2007.com/pdf/Prion%20Book%20of%20Abstracts.pdf
full text ;
ATYPICAL NOR-98 SCRAPIE LOCATION UPDATE ON 5 DOCUMENTED CASES THIS YEAR ;
The flocks of origin are WY, CO, CA, IN, and MN.
personal communication USDA et al. ...TSS
http://nor-98.blogspot.com/
never forget what deepthroat told me in 2000-2001. this person was high official in USDA. ...tss
============================================================
The most frightening thing I have read all day is the report of Gambetti's finding of a new strain of sporadic cjd in young people.........Dear God, what in the name of all that is holy is that!!! If the US has different strains of scrapie.....why????than the UK...then would the same mechanisms that make different strains of scrapie here make different strains of BSE...if the patterns are different in sheep and mice for scrapie.....could not the BSE be different in the cattle, in the mink, in the humans.......I really think the slides or tissues and everything from these young people with the new strain of sporadic cjd should be put up to be analyzed by many, many experts in cjd........bse.....scrapie Scrape the damn slide and put it into mice.....wait.....chop up the mouse brain and and spinal cord........put into some more mice.....dammit amplify the thing and start the damned research.....This is NOT rocket science...we need to use what we know and get off our butts and move....the whining about how long everything takes.....well it takes a whole lot longer if you whine for a year and then start the research!!! Not sure where I read this but it was a recent press release or something like that: I thought I would fall out of my chair when I read about how there was no worry about infectivity from a histopath slide or tissues because they are preserved in formic acid, or formalin or formaldehyde.....for God's sake........ Ask any pathologist in the UK what the brain tissues in the formalin looks like after a year.......it is a big fat sponge...the agent continues to eat the brain ......you can't make slides anymore because the agent has never stopped........and the old slides that are stained with Hemolysin and Eosin......they get holier and holier and degenerate and continue...what you looked at 6 months ago is not there........Gambetti better be photographing every damned thing he is looking at.....
Okay, you need to know. You don't need to pass it on as nothing will come of it and there is not a damned thing anyone can do about it. Don't even hint at it as it will be denied and laughed at.......... USDA is gonna do as little as possible until there is actually a human case in the USA of the nvcjd........if you want to move this thing along and shake the earth....then we gotta get the victims families to make sure whoever is doing the autopsy is credible, trustworthy, and a saint with the courage of Joan of Arc........I am not kidding!!!! so, unless we get a human death from EXACTLY the same form with EXACTLY the same histopath lesions as seen in the UK nvcjd........forget any action........it is ALL gonna be sporadic!!!
And, if there is a case.......there is gonna be every effort to link it to international travel, international food, etc. etc. etc. etc. etc. They will go so far as to find out if a sex partner had ever traveled to the UK/europe, etc. etc. .... It is gonna be a long, lonely, dangerous twisted journey to the truth. They have all the cards, all the money, and are willing to threaten and carry out those threats....and this may be their biggest downfall...
Thanks as always for your help. (Recently had a very startling revelation from a rather senior person in government here..........knocked me out of my chair........you must keep pushing. If I was a power person....I would be demanding that there be a least a million bovine tested as soon as possible and agressively seeking this disease. The big players are coming out of the woodwork as there is money to be made!!! In short: "FIRE AT WILL"!!! for the very dumb....who's "will"! "Will be the burden to bare if there is any coverup!"
again it was said years ago and it should be taken seriously....BSE will NEVER be found in the US! As for the BSE conference call...I think you did a great service to freedom of information and making some people feign integrity...I find it scary to see that most of the "experts" are employed by the federal government or are supported on the "teat" of federal funds. A scary picture! I hope there is a confidential panel organized by the new government to really investigate this thing.
You need to watch your back........but keep picking at them.......like a buzzard to the bone...you just may get to the truth!!! (You probably have more support than you know. Too many people are afraid to show you or let anyone else know. I have heard a few things myself... you ask the questions that everyone else is too afraid to ask.)
================================================================
2008
considering the BASE strains of atypical BSE are more virulent to humans, considering the BASE resembles that of the some subtypes of sporadic CJD and GSS, considering all this, IF i were the USDA et al, i would be more worried about getting all the potentially tainted mad cow blood back, than the damn plaque. ..
P.S. Gambetti et al recently said that the BASE atypical BSE are more virulent to humans. other scientists have said the same thing. however Gambetti claims it does not resemble sCJD, but every other scientist says it does. you be the judge.........
Evaluation of the Human Transmission Risk of an Atypical Bovine Spongiform Encephalopathy Prion Strain
J. Virol. doi:10.1128/JVI.02561-07
Minimal brain spongiosis and long incubation time are observed in the BASE-infected Tg mice. These results suggest that, in humans, BASE is a more virulent BSE strain and likely lymphotropic.
http://jvi.asm.org/cgi/content/abstract/JVI.02561-07v1?papetoc
for those interested, further into this study, it gets very interesting ;
http://cjdmadcowbaseoct2007.blogspot.com/2008/02/evaluation-of-human-transmission-risk.html
CJD QUESTIONNAIRE
http://cjdquestionnaire.blogspot.com/
[Docket No. FSIS-2006-0011] FSIS Harvard Risk Assessment of Bovine Spongiform Encephalopathy (BSE)
http://www.fsis.usda.gov/OPPDE/Comments/2006-0011/2006-0011-1.pdf
suppressed peer review of Harvard study October 31, 2002
http://www.fsis.usda.gov/oa/topics/BSE_Peer_Review.pdf
APHIS-2006-0041-0006 TSE advisory committee for the meeting December 15, 2006
http://www.regulations.gov/fdmspublic/ContentViewer?objectId=09000064801f3413&disposition=attachment&contentType=msw8
Attachment to Singeltary comment
January 28, 2007
Greetings APHIS,
I would kindly like to submit the following to ;
BSE; MRR; IMPORTATION OF LIVE BOVINES AND PRODUCTS DERIVED FROM BOVINES [Docket No. APHIS-2006-0041] RIN 0579-AC01
[Federal Register: January 9, 2007 (Volume 72, Number 5)] [Proposed Rules] [Page 1101-1129] From the Federal Register Online via GPO Access [wais.access.gpo.gov] [DOCID:fr09ja07-21]
http://www.regulations.gov/fdmspublic/component/main?main=DocumentDetail&o=09000064801f8152
BSE; MRR; IMPORTATION OF LIVE BOVINES AND PRODUCTS DERIVED FROM BOVINES [Docket No. APHIS-2006-0041] RIN 0579-AC01 Date: January 9, 2007 at 9:08 am PST
http://www.regulations.gov/fdmspublic/component/main?main=DocumentDetail&o=09000064801f3412
Web posted Friday, January 23, 1998 5:49 a.m. CT
TSS
Witness testifies some ill cattle sent to rendering plant
By CHIP CHANDLER Globe-News Staff Writer
snip...
Mike Engler -- son of Paul Engler, the original plaintiff and owner of Cactus Feeders Inc. -- agreed that more than 10 cows with some sort of central nervous system disorder were sent to Hereford By-Products.
The younger Engler, who has a doctorate in biochemistry from Johns Hopkins University, was the only witness jurors heard Thursday in the Oprah Winfrey defamation trial. His testimony will resume this morning.
According to a U.S. Department of Agriculture report from which Winfrey attorney Charles Babcock quoted, encephalitis caused by unknown reasons could be a warning sign for bovine spongiform encephalopathy, or mad cow disease.
Encephalitis was indicated on the death certificates -- or ``dead slips'' -- of three Cactus Feeders cows discussed in court. The slips then were stamped, ``Picked up by your local used cattle dealer'' before the carcasses were taken to the rendering plant.
snip...
http://www.amarillonet.com/
FOR IMMEDIATE RELEASE Statement May 4, 2004 Media Inquiries: 301-827-6242 Consumer Inquiries: 888-INFO-FDA
Statement on Texas Cow With Central Nervous System Symptoms On Friday, April 30 th , the Food and Drug Administration learned that a cow with central nervous system symptoms had been killed and shipped to a processor for rendering into animal protein for use in animal feed.
FDA, which is responsible for the safety of animal feed, immediately began an investigation. On Friday and throughout the weekend, FDA investigators inspected the slaughterhouse, the rendering facility, the farm where the animal came from, and the processor that initially received the cow from the slaughterhouse.
FDA's investigation showed that the animal in question had already been rendered into "meat and bone meal" (a type of protein animal feed). Over the weekend FDA was able to track down all the implicated material. That material is being held by the firm, which is cooperating fully with FDA.
Cattle with central nervous system symptoms are of particular interest because cattle with bovine spongiform encephalopathy or BSE, also known as "mad cow disease," can exhibit such symptoms. In this case, there is no way now to test for BSE. But even if the cow had BSE, FDA's animal feed rule would prohibit the feeding of its rendered protein to other ruminant animals (e.g., cows, goats, sheep, bison).
FDA is sending a letter to the firm summarizing its findings and informing the firm that FDA will not object to use of this material in swine feed only. If it is not used in swine feed, this material will be destroyed. Pigs have been shown not to be susceptible to BSE. If the firm agrees to use the material for swine feed only, FDA will track the material all the way through the supply chain from the processor to the farm to ensure that the feed is properly monitored and used only as feed for pigs.
To protect the U.S. against BSE, FDA works to keep certain mammalian protein out of animal feed for cattle and other ruminant animals. FDA established its animal feed rule in 1997 after the BSE epidemic in the U.K. showed that the disease spreads by feeding infected ruminant protein to cattle.
Under the current regulation, the material from this Texas cow is not allowed in feed for cattle or other ruminant animals. FDA's action specifying that the material go only into swine feed means also that it will not be fed to poultry.
FDA is committed to protecting the U.S. from BSE and collaborates closely with the U.S. Department of Agriculture on all BSE issues. The animal feed rule provides crucial protection against the spread of BSE, but it is only one of several such firewalls. FDA will soon be improving the animal feed rule, to make this strong system even stronger.
####
http://www.fda.gov/bbs/topics/news/2004/NEW01061.html
Beef - Westland/Hallmark Recall OF BEEF WITH DEADSTOCK DOWNER COWS, THE MOST HIGH RISK CATTLE FOR BSE/TSE AKA MAD COW DISEASE
Additional Products Listing 5-20-08
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
TOTAL DISTRIBUTION LIST
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20All%20Dist042008.pdf
ADDITIONAL PRODUCTS CONTAINING RECALLED BEEF
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
SEE FULL LIST OF ALL RECALLED SUSPECT DEAD STOCK DOWNER COW PRODUCTS HERE ;
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
>>>In the papers, the government alleges the meatpacking plant slaughtered and processed downer cows for nearly four years — from January 2004 to September 2007 — <<<
>> 95%) downer or dead dairy cattle and a few horses. Sheep had never been fed.
We believe that these findings may indicate the presence of a previously unrecognized scrapie-like disease in cattle and wish to alert dairy practitioners to this possibility.
snip...
PROCEEDINGS OF THE SEVENTH ANNUAL WESTERN CONFERENCE FOR FOOD ANIMAL VETERINARY MEDICINE, University of Arizona, March 17-19, 1986
http://web.archive.org/web/20030331063559/http://www.bseinquiry.gov.uk/files/mb/m09a/tab01.pdf
http://web.archive.org/web/20030516051623/http://www.bseinquiry.gov.uk/files/mb/m09/tab05.pdf
IN CONFIDENCE
PERCEPTIONS OF UNCONVENTIONAL SLOW VIRUS DISEASES OF ANIMALS IN THE USA
http://collections.europarchive.org/tna/20080102193705/http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf
TSS
Friday, March 7, 2008
Thursday, March 6, 2008
USDA to Hallmark: We want our plaque back
Legal/Regulatory News USDA to Hallmark: We want our plaque back
By Janie Gabbett on 3/6/2008 for Meatingplace.com
USDA's Agricultural Marketing Service has formally rescinded Hallmark/Westland Meat Packing Co.'s supplier of the year award from the 2004/2005 school year and requested they return the physical award, which was a plaque.
"The award was rescinded because of evidence FSIS obtained that the establishment had the practice of occasionally slaughtering cattle that, although the cattle passed ante-mortem inspection, became non-ambulatory prior to entering the slaughter operation," USDA spokeswoman Angela Harless told Meatingplace.com.
Since 2000, AMS has not allowed nonambulatory cattle to be processed for sale as beef to AMS for distribution through USDA's Food and Nutrition Service to programs like the school lunch program.
The plaque is probably the least of Hallmark's worries. CEO Steven Mendell has been subpoenaed to appear before a House committee next week to explain downer cow animal abuse at the Chino, Calif. plant that led to the largest beef recall in history.
http://www.meatingplace.com/MembersOnly/webNews/details.aspx?item=19985
all the ones exposed to BSE/BASE/TSE mad cow are now cured i guess. the ones that might die in the years, decade to come, well, they will be forgotten. problem solved. it will all go back to sporadic CJD. the utter absurdity of it all. round and round we go. BUT, bbbut, at least the USDA will have their damn plaque back. ...TSS
''WE WANT OUR PLAQUE BACK'' ???
myself and many more want our loved ones back.
holy mad cow, when you don't think it can get any dumber, old dumb and dumber pull through i.e. USDA et al. ...TSS
===========================================================
===========================================================
Archive Number 20080306.0915 Published Date 06-MAR-2008 Subject PRO/AH> Beef recall - USA (06)
BEEF RECALL - USA (06) ********************** A ProMED-mail post
ProMED-mail is a program of the International Society for Infectious Diseases
[1] Date: Mon 3 Mar 2008 16:30:24 -0600 From: Tim Snider
Re: Beef recall - USA (05) 20080229.0823
----------------------------------------
Your comment on the posting above about healthy cows with acute injuries straining credulity [my interpretation of your comment. - Mod.MHJ]
I can personally attest to seeing enough healthy cattle with broken legs, dislocated hips, etc. in abattoir holding pens, vet clinic squeeze tubs, sale barn holding pens, owner pens, etc. A slippery concrete surface, a leg through the slats in a cattle panel followed by the right 'push', or a combination of various and sundry factors allows these unfortunate events to occur. With only 3 years in mixed animal full time practice, I admit my numerator for this field observation is small, but so would be my denominator. I can only guess that potential beef wastage from acutely injured cattle in a large facility would be potentially significant.
-- Timothy Snider, DVM, PhD, DACVP Oklahoma State University USA
[All I can say is that it is a matter of perception. Clinicians deal primarily with numerators and thus the world can seem to be inhabited by the sick and the lame. As an epidemiologist I deal in population denominators, which provides a very different viewpoint. We can agree to differ. But, be that as it may, the current FSIS (Food Safety and Inspection Service) rules have been the following for years:
1. Downers (non-ambulatory animals) cannot and will not enter the food chain. 2. Injured but otherwise ambulatory and healthy animals can enter the food chain after an ante-mortem inspection by a FSIS Public Health Veterinarian. This, of course, is always subject to post-mortem inspection assuming the animal had passed the ante-mortem inspection.
By definition an animal with a broken or badly sprained limb is non-ambulatory. This subthread is now cut.
The California Department of Public Health has listed some 3000 restaurants and other businesses that may have received over the past 2 years some of the Hallmark/Westland Meat Co beef subject for recall. This list may be somewhat inflated as some food distributors say that they gave the CA PH office their entire customer list rather than a specific roster of the restaurants that purchased their recalled beef.
Hallmark / Westland Meat Recall - Retail Distribution (with caveats)
http://dhs.ca.gov/fdb/local/PDF/WestlandRecallRetailDistributionConsolidatedForWeb2-29-08.PDF
plus,
Additional Products Containing Westland Recalled Beef
http://dhs.ca.gov/fdb/local/PDF/AdditionalProductsContainingWestlandRecalledBeef2-29-08.PDF
The good news is that in the short-term there are as yet apparently no ill effects from the distribution of these meats. The bad news is that if a bovine TSE (transmissible spongiform encephalitis) were involved it will be some 5-10 years before any human cases might be seen. One must always be aware of Sherlock Holmes' comment on the difference between seeing and observing. The wide distribution of these meats will confuse future investigations and retrospective studies because of the uncertainty and possibility of a past exposure. As an epidemiologist I am all too aware of the shortcuts taken by my colleagues in ascribing cause. It has definitely muddied the waters. - Mod.MHJ]
****** [2] Date: Sat 1 Mar 2008 Source: The New York Times, Associated Press report [edited]
The Department of Agriculture has suspended at least 2 federal meat inspectors after the largest beef recall in the nation's history, a union head said Friday [29 Feb 2008].
The official, Stan Painter, chairman of the National Joint Council of Food Inspection Locals, said that the department had confirmed that it had placed a veterinarian and a floor inspector from the Westland/Hallmark Meat Company in Chino, California, on paid administrative leave. A department spokeswoman said the agency could not comment on the investigation or on personnel matters.
-- Communicated by: ProMED-mail
[see also: Beef recall - USA (05) 20080229.0823 Beef recall - USA (04): Nationwide 20080227.0799 Beef recall - USA (03): CA 20080226.0771 Beef recall - USA (02): (CA) 20080222.0720 Beef recall - USA: (CA), food safety questions 20080218.0651] ...................................mhj/mj/dk
*##########################################################* ************************************************************
http://www.promedmail.org/pls/otn/f?p=2400:1001:3740676921442591::NO::F2400_P1001_BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,71708
Wednesday, February 27, 2008 BEEF RECALL NATIONWIDE - SCHOOL LUNCH PROGRAM UPDATE
http://downercattle.blogspot.com/2008/02/beef-recall-nationwide-school-lunch.html
CJD QUESTIONNAIRE
http://cjdquestionnaire.blogspot.com/
Specified Risk Material SRM
http://madcowspontaneousnot.blogspot.com/2008/02/specified-risk-materials-srm.html
Beef - Westland/Hallmark Recall OF BEEF WITH DEADSTOCK DOWNER COWS, THE MOST HIGH RISK CATTLE FOR BSE/TSE AKA MAD COW DISEASE
Additional Products Listing 5-20-08
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
TOTAL DISTRIBUTION LIST
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20All%20Dist042008.pdf
ADDITIONAL PRODUCTS CONTAINING RECALLED BEEF
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
SEE FULL LIST OF ALL RECALLED SUSPECT DEAD STOCK DOWNER COW PRODUCTS HERE ;
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
Beef - Westland/Hallmark Recall OF BEEF WITH DEADSTOCK DOWNER COWS, THE MOST HIGH RISK CATTLE FOR BSE/TSE AKA MAD COW DISEASE
Additional Products Listing 5-20-08
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
TOTAL DISTRIBUTION LIST
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20All%20Dist042008.pdf
ADDITIONAL PRODUCTS CONTAINING RECALLED BEEF
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
SEE FULL LIST OF ALL RECALLED SUSPECT DEAD STOCK DOWNER COW PRODUCTS HERE ;
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
>>>In the papers, the government alleges the meatpacking plant slaughtered and processed downer cows for nearly four years — from January 2004 to September 2007 — <<<
>> 95%) downer or dead dairy cattle and a few horses. Sheep had never been fed.
We believe that these findings may indicate the presence of a previously unrecognized scrapie-like disease in cattle and wish to alert dairy practitioners to this possibility.
snip...
PROCEEDINGS OF THE SEVENTH ANNUAL WESTERN CONFERENCE FOR FOOD ANIMAL VETERINARY MEDICINE, University of Arizona, March 17-19, 1986
http://web.archive.org/web/20030331063559/http://www.bseinquiry.gov.uk/files/mb/m09a/tab01.pdf
http://web.archive.org/web/20030516051623/http://www.bseinquiry.gov.uk/files/mb/m09/tab05.pdf
IN CONFIDENCE
PERCEPTIONS OF UNCONVENTIONAL SLOW VIRUS DISEASES OF ANIMALS IN THE USA
http://collections.europarchive.org/tna/20080102193705/http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf
TSS
By Janie Gabbett on 3/6/2008 for Meatingplace.com
USDA's Agricultural Marketing Service has formally rescinded Hallmark/Westland Meat Packing Co.'s supplier of the year award from the 2004/2005 school year and requested they return the physical award, which was a plaque.
"The award was rescinded because of evidence FSIS obtained that the establishment had the practice of occasionally slaughtering cattle that, although the cattle passed ante-mortem inspection, became non-ambulatory prior to entering the slaughter operation," USDA spokeswoman Angela Harless told Meatingplace.com.
Since 2000, AMS has not allowed nonambulatory cattle to be processed for sale as beef to AMS for distribution through USDA's Food and Nutrition Service to programs like the school lunch program.
The plaque is probably the least of Hallmark's worries. CEO Steven Mendell has been subpoenaed to appear before a House committee next week to explain downer cow animal abuse at the Chino, Calif. plant that led to the largest beef recall in history.
http://www.meatingplace.com/MembersOnly/webNews/details.aspx?item=19985
all the ones exposed to BSE/BASE/TSE mad cow are now cured i guess. the ones that might die in the years, decade to come, well, they will be forgotten. problem solved. it will all go back to sporadic CJD. the utter absurdity of it all. round and round we go. BUT, bbbut, at least the USDA will have their damn plaque back. ...TSS
''WE WANT OUR PLAQUE BACK'' ???
myself and many more want our loved ones back.
holy mad cow, when you don't think it can get any dumber, old dumb and dumber pull through i.e. USDA et al. ...TSS
===========================================================
===========================================================
Archive Number 20080306.0915 Published Date 06-MAR-2008 Subject PRO/AH> Beef recall - USA (06)
BEEF RECALL - USA (06) ********************** A ProMED-mail post
ProMED-mail is a program of the International Society for Infectious Diseases
[1] Date: Mon 3 Mar 2008 16:30:24 -0600 From: Tim Snider
Re: Beef recall - USA (05) 20080229.0823
----------------------------------------
Your comment on the posting above about healthy cows with acute injuries straining credulity [my interpretation of your comment. - Mod.MHJ]
I can personally attest to seeing enough healthy cattle with broken legs, dislocated hips, etc. in abattoir holding pens, vet clinic squeeze tubs, sale barn holding pens, owner pens, etc. A slippery concrete surface, a leg through the slats in a cattle panel followed by the right 'push', or a combination of various and sundry factors allows these unfortunate events to occur. With only 3 years in mixed animal full time practice, I admit my numerator for this field observation is small, but so would be my denominator. I can only guess that potential beef wastage from acutely injured cattle in a large facility would be potentially significant.
-- Timothy Snider, DVM, PhD, DACVP Oklahoma State University USA
[All I can say is that it is a matter of perception. Clinicians deal primarily with numerators and thus the world can seem to be inhabited by the sick and the lame. As an epidemiologist I deal in population denominators, which provides a very different viewpoint. We can agree to differ. But, be that as it may, the current FSIS (Food Safety and Inspection Service) rules have been the following for years:
1. Downers (non-ambulatory animals) cannot and will not enter the food chain. 2. Injured but otherwise ambulatory and healthy animals can enter the food chain after an ante-mortem inspection by a FSIS Public Health Veterinarian. This, of course, is always subject to post-mortem inspection assuming the animal had passed the ante-mortem inspection.
By definition an animal with a broken or badly sprained limb is non-ambulatory. This subthread is now cut.
The California Department of Public Health has listed some 3000 restaurants and other businesses that may have received over the past 2 years some of the Hallmark/Westland Meat Co beef subject for recall. This list may be somewhat inflated as some food distributors say that they gave the CA PH office their entire customer list rather than a specific roster of the restaurants that purchased their recalled beef.
Hallmark / Westland Meat Recall - Retail Distribution (with caveats)
http://dhs.ca.gov/fdb/local/PDF/WestlandRecallRetailDistributionConsolidatedForWeb2-29-08.PDF
plus,
Additional Products Containing Westland Recalled Beef
http://dhs.ca.gov/fdb/local/PDF/AdditionalProductsContainingWestlandRecalledBeef2-29-08.PDF
The good news is that in the short-term there are as yet apparently no ill effects from the distribution of these meats. The bad news is that if a bovine TSE (transmissible spongiform encephalitis) were involved it will be some 5-10 years before any human cases might be seen. One must always be aware of Sherlock Holmes' comment on the difference between seeing and observing. The wide distribution of these meats will confuse future investigations and retrospective studies because of the uncertainty and possibility of a past exposure. As an epidemiologist I am all too aware of the shortcuts taken by my colleagues in ascribing cause. It has definitely muddied the waters. - Mod.MHJ]
****** [2] Date: Sat 1 Mar 2008 Source: The New York Times, Associated Press report [edited]
The Department of Agriculture has suspended at least 2 federal meat inspectors after the largest beef recall in the nation's history, a union head said Friday [29 Feb 2008].
The official, Stan Painter, chairman of the National Joint Council of Food Inspection Locals, said that the department had confirmed that it had placed a veterinarian and a floor inspector from the Westland/Hallmark Meat Company in Chino, California, on paid administrative leave. A department spokeswoman said the agency could not comment on the investigation or on personnel matters.
-- Communicated by: ProMED-mail
[see also: Beef recall - USA (05) 20080229.0823 Beef recall - USA (04): Nationwide 20080227.0799 Beef recall - USA (03): CA 20080226.0771 Beef recall - USA (02): (CA) 20080222.0720 Beef recall - USA: (CA), food safety questions 20080218.0651] ...................................mhj/mj/dk
*##########################################################* ************************************************************
http://www.promedmail.org/pls/otn/f?p=2400:1001:3740676921442591::NO::F2400_P1001_BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,71708
Wednesday, February 27, 2008 BEEF RECALL NATIONWIDE - SCHOOL LUNCH PROGRAM UPDATE
http://downercattle.blogspot.com/2008/02/beef-recall-nationwide-school-lunch.html
CJD QUESTIONNAIRE
http://cjdquestionnaire.blogspot.com/
Specified Risk Material SRM
http://madcowspontaneousnot.blogspot.com/2008/02/specified-risk-materials-srm.html
Beef - Westland/Hallmark Recall OF BEEF WITH DEADSTOCK DOWNER COWS, THE MOST HIGH RISK CATTLE FOR BSE/TSE AKA MAD COW DISEASE
Additional Products Listing 5-20-08
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
TOTAL DISTRIBUTION LIST
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20All%20Dist042008.pdf
ADDITIONAL PRODUCTS CONTAINING RECALLED BEEF
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
SEE FULL LIST OF ALL RECALLED SUSPECT DEAD STOCK DOWNER COW PRODUCTS HERE ;
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
Beef - Westland/Hallmark Recall OF BEEF WITH DEADSTOCK DOWNER COWS, THE MOST HIGH RISK CATTLE FOR BSE/TSE AKA MAD COW DISEASE
Additional Products Listing 5-20-08
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
TOTAL DISTRIBUTION LIST
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20All%20Dist042008.pdf
ADDITIONAL PRODUCTS CONTAINING RECALLED BEEF
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
SEE FULL LIST OF ALL RECALLED SUSPECT DEAD STOCK DOWNER COW PRODUCTS HERE ;
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
>>>In the papers, the government alleges the meatpacking plant slaughtered and processed downer cows for nearly four years — from January 2004 to September 2007 — <<<
>> 95%) downer or dead dairy cattle and a few horses. Sheep had never been fed.
We believe that these findings may indicate the presence of a previously unrecognized scrapie-like disease in cattle and wish to alert dairy practitioners to this possibility.
snip...
PROCEEDINGS OF THE SEVENTH ANNUAL WESTERN CONFERENCE FOR FOOD ANIMAL VETERINARY MEDICINE, University of Arizona, March 17-19, 1986
http://web.archive.org/web/20030331063559/http://www.bseinquiry.gov.uk/files/mb/m09a/tab01.pdf
http://web.archive.org/web/20030516051623/http://www.bseinquiry.gov.uk/files/mb/m09/tab05.pdf
IN CONFIDENCE
PERCEPTIONS OF UNCONVENTIONAL SLOW VIRUS DISEASES OF ANIMALS IN THE USA
http://collections.europarchive.org/tna/20080102193705/http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf
TSS
House committee subpoenas Hallmark/Westland CEO - i call for an investigation of the investigators
----- Original Message -----
From: "Terry S. Singeltary Sr." To: Sent: Thursday, March 06, 2008 12:15 PM Subject: [BSE-L] House committee subpoenas Hallmark/Westland CEO - i call for an investigation of the investigators
March 5, 2008, 1:48PM Lawmakers Subpoena Beef-Recall Executive
By MATTHEW PERRONE By AP Business Writer © 2008 The Associated Press
http://www.chron.com/disp/story.mpl/ap/fn/5595237.html
3/6/2008
i call for an investigation of the investigators
>>>House committee subpoenas Hallmark/Westland CEO The subpoena orders him to testify at a March 12 hearing titled "Regulatory Failure: Must America Live With Unsafe Food?"<<<
what a hoot. the ones that should be subpoenad and held accountable are the very ones on the committee. they have failed the public for years about BSE risk and regulations. the very people that are going to investigate this thing are the very folks responsible for all the children and elderly that were exposed to the potential of mad cow via non-ambulatory i.e. DOWNERS, the most likely to have a TSE. waxman et al have been claiming to be concerned about BSE aka mad cow disease's and one issue was the non-ambulatory 'downer' cattle, and i quote waxman; Failure To Test Staggering Cow May Reflect Wider Problems Rep. Waxman raises concerns that the recent failure of USDA to test an impaired cow for BSE may not be an isolated incident, citing the failure of USDA to monitor whether cows condemned for central nervous system symptoms are actually tested for mad cow disease.
http://reform.democrats.house.gov/documents/20040607142914-86912.pdf
http://oversight.house.gov/documents/20040607142914-86912.pdf
folks, that was in 2004. why, in 2008, why are we still discussing the same failures$$$
THE PEOPLE BELOW SHOULD ALL BE SUBPOENAED AS WELL FOR THEIR CONTINUED FAILURES TO PROTECT THE CONSUMER FROM MAD COW DISEASE. and i call for an investigation of the investigators below. why in 2008 are we still floundering$$$
Committee on Energy and Commerce Subcommittee on Oversight and Investigations
http://energycommerce.house.gov/Subcommittees/ovin.shtml
Wednesday, February 27, 2008
BEEF RECALL NATIONWIDE - SCHOOL LUNCH PROGRAM UPDATE
http://downercattle.blogspot.com/2008/02/beef-recall-nationwide-school-lunch.html
CJD QUESTIONNAIRE
http://cjdquestionnaire.blogspot.com/
Specified Risk Material SRM
http://madcowspontaneousnot.blogspot.com/2008/02/specified-risk-materials-srm.html
Wednesday, February 27, 2008
BEEF RECALL NATIONWIDE - SCHOOL LUNCH PROGRAM UPDATE
http://downercattle.blogspot.com/2008/02/beef-recall-nationwide-school-lunch.html
Specified Risk Material SRM
http://madcowspontaneousnot.blogspot.com/2008/02/specified-risk-materials-srm.html
Beef - Westland/Hallmark Recall OF BEEF WITH DEADSTOCK DOWNER COWS, THE MOST HIGH RISK CATTLE FOR BSE/TSE AKA MAD COW DISEASE
Additional Products Listing 5-20-08
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
TOTAL DISTRIBUTION LIST
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20All%20Dist042008.pdf
ADDITIONAL PRODUCTS CONTAINING RECALLED BEEF
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
SEE FULL LIST OF ALL RECALLED SUSPECT DEAD STOCK DOWNER COW PRODUCTS HERE ;
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
Beef - Westland/Hallmark Recall OF BEEF WITH DEADSTOCK DOWNER COWS, THE MOST HIGH RISK CATTLE FOR BSE/TSE AKA MAD COW DISEASE
Additional Products Listing 5-20-08
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
TOTAL DISTRIBUTION LIST
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20All%20Dist042008.pdf
ADDITIONAL PRODUCTS CONTAINING RECALLED BEEF
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
SEE FULL LIST OF ALL RECALLED SUSPECT DEAD STOCK DOWNER COW PRODUCTS HERE ;
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
>>>In the papers, the government alleges the meatpacking plant slaughtered and processed downer cows for nearly four years — from January 2004 to September 2007 — <<< >> 95%) downer or dead dairy cattle and a few horses. Sheep had never been fed.
We believe that these findings may indicate the presence of a previously unrecognized scrapie-like disease in cattle and wish to alert dairy practitioners to this possibility.
snip...
PROCEEDINGS OF THE SEVENTH ANNUAL WESTERN CONFERENCE FOR FOOD ANIMAL VETERINARY MEDICINE, University of Arizona, March 17-19, 1986
http://web.archive.org/web/20030331063559/http://www.bseinquiry.gov.uk/files/mb/m09a/tab01.pdf
http://web.archive.org/web/20030516051623/http://www.bseinquiry.gov.uk/files/mb/m09/tab05.pdf
IN CONFIDENCE
PERCEPTIONS OF UNCONVENTIONAL SLOW VIRUS DISEASES OF ANIMALS IN THE USA
http://collections.europarchive.org/tna/20080102193705/http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf
TSS
From: "Terry S. Singeltary Sr." To: Sent: Thursday, March 06, 2008 12:15 PM Subject: [BSE-L] House committee subpoenas Hallmark/Westland CEO - i call for an investigation of the investigators
March 5, 2008, 1:48PM Lawmakers Subpoena Beef-Recall Executive
By MATTHEW PERRONE By AP Business Writer © 2008 The Associated Press
http://www.chron.com/disp/story.mpl/ap/fn/5595237.html
3/6/2008
i call for an investigation of the investigators
>>>House committee subpoenas Hallmark/Westland CEO The subpoena orders him to testify at a March 12 hearing titled "Regulatory Failure: Must America Live With Unsafe Food?"<<<
what a hoot. the ones that should be subpoenad and held accountable are the very ones on the committee. they have failed the public for years about BSE risk and regulations. the very people that are going to investigate this thing are the very folks responsible for all the children and elderly that were exposed to the potential of mad cow via non-ambulatory i.e. DOWNERS, the most likely to have a TSE. waxman et al have been claiming to be concerned about BSE aka mad cow disease's and one issue was the non-ambulatory 'downer' cattle, and i quote waxman; Failure To Test Staggering Cow May Reflect Wider Problems Rep. Waxman raises concerns that the recent failure of USDA to test an impaired cow for BSE may not be an isolated incident, citing the failure of USDA to monitor whether cows condemned for central nervous system symptoms are actually tested for mad cow disease.
http://reform.democrats.house.gov/documents/20040607142914-86912.pdf
http://oversight.house.gov/documents/20040607142914-86912.pdf
folks, that was in 2004. why, in 2008, why are we still discussing the same failures$$$
THE PEOPLE BELOW SHOULD ALL BE SUBPOENAED AS WELL FOR THEIR CONTINUED FAILURES TO PROTECT THE CONSUMER FROM MAD COW DISEASE. and i call for an investigation of the investigators below. why in 2008 are we still floundering$$$
Committee on Energy and Commerce Subcommittee on Oversight and Investigations
http://energycommerce.house.gov/Subcommittees/ovin.shtml
Wednesday, February 27, 2008
BEEF RECALL NATIONWIDE - SCHOOL LUNCH PROGRAM UPDATE
http://downercattle.blogspot.com/2008/02/beef-recall-nationwide-school-lunch.html
CJD QUESTIONNAIRE
http://cjdquestionnaire.blogspot.com/
Specified Risk Material SRM
http://madcowspontaneousnot.blogspot.com/2008/02/specified-risk-materials-srm.html
Wednesday, February 27, 2008
BEEF RECALL NATIONWIDE - SCHOOL LUNCH PROGRAM UPDATE
http://downercattle.blogspot.com/2008/02/beef-recall-nationwide-school-lunch.html
Specified Risk Material SRM
http://madcowspontaneousnot.blogspot.com/2008/02/specified-risk-materials-srm.html
Beef - Westland/Hallmark Recall OF BEEF WITH DEADSTOCK DOWNER COWS, THE MOST HIGH RISK CATTLE FOR BSE/TSE AKA MAD COW DISEASE
Additional Products Listing 5-20-08
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
TOTAL DISTRIBUTION LIST
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20All%20Dist042008.pdf
ADDITIONAL PRODUCTS CONTAINING RECALLED BEEF
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
SEE FULL LIST OF ALL RECALLED SUSPECT DEAD STOCK DOWNER COW PRODUCTS HERE ;
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
Beef - Westland/Hallmark Recall OF BEEF WITH DEADSTOCK DOWNER COWS, THE MOST HIGH RISK CATTLE FOR BSE/TSE AKA MAD COW DISEASE
Additional Products Listing 5-20-08
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
TOTAL DISTRIBUTION LIST
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20All%20Dist042008.pdf
ADDITIONAL PRODUCTS CONTAINING RECALLED BEEF
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
SEE FULL LIST OF ALL RECALLED SUSPECT DEAD STOCK DOWNER COW PRODUCTS HERE ;
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
>>>In the papers, the government alleges the meatpacking plant slaughtered and processed downer cows for nearly four years — from January 2004 to September 2007 — <<< >> 95%) downer or dead dairy cattle and a few horses. Sheep had never been fed.
We believe that these findings may indicate the presence of a previously unrecognized scrapie-like disease in cattle and wish to alert dairy practitioners to this possibility.
snip...
PROCEEDINGS OF THE SEVENTH ANNUAL WESTERN CONFERENCE FOR FOOD ANIMAL VETERINARY MEDICINE, University of Arizona, March 17-19, 1986
http://web.archive.org/web/20030331063559/http://www.bseinquiry.gov.uk/files/mb/m09a/tab01.pdf
http://web.archive.org/web/20030516051623/http://www.bseinquiry.gov.uk/files/mb/m09/tab05.pdf
IN CONFIDENCE
PERCEPTIONS OF UNCONVENTIONAL SLOW VIRUS DISEASES OF ANIMALS IN THE USA
http://collections.europarchive.org/tna/20080102193705/http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf
TSS
California lists possible recipients of recalled non-ambulatory 'DOWNER' (high potential for TSE) Hallmark beef
Food Safety
California lists possible recipients of recalled Hallmark beef
By Janie Gabbett on 3/5/2008 for Meatingplace.com
It took the California Department of Public Health 120 pages to list nearly 3,000 restaurants and other businesses in the state that may have received some of the two years' worth of beef that Hallmark/Westland Meat Co. recalled last month.
The list, viewable on www.cdph.ca.gov, could be over the top, however. Some food distributors told Nation's Restaurant News they gave California officials their entire customer list rather than a roster of the restaurants that purchased the recalled beef.
The agency has also posted a list of products recalled by companies including ConAgra Foods, Kirkland, General Mills, Nestle and Richwood Meat because they could have contained meat involved in the recall.
No illnesses have been linked to the Class II recall that USDA prompted after videos shot by the Humane Society of the United States revealed animal handling of downer cows that were out of compliance with USDA's animal welfare rules.
Under current federal rules, retailers of recalled products are not revealed. California law, however, allows the state to reveal the names of businesses that may be selling the food in question. Some consumer groups and U.S. legislators have been calling for federal rule changes to allow such listings nationwide.
http://meatingplace.com/MembersOnly/webNews/details.aspx?item=19962
>>>No illnesses have been linked to the Class II recall that USDA prompted after videos shot by the Humane Society of the United States revealed animal handling of downer cows that were out of compliance with USDA's animal welfare rules. <<<
href="http://dhs.ca.gov/fdb/local/PDF/WestlandRecallRetailDistributionConsolidatedForWeb2-29-08.PDF">http://dhs.ca.gov/fdb/local/PDF/WestlandRecallRetailDistributionConsolidatedForWeb2-29-08.PDF
Additional Products Containing Westland Recalled Beef
http://dhs.ca.gov/fdb/local/PDF/AdditionalProductsContainingWestlandRecalledBeef2-29-08.PDF
IF the USDA and the FDA et al were not in bed with the industry so much, they would come clean with the rest of the states, and produce a list for the public from each state as was done in California. THAT'S just one state folks. nope, all the BSe about how No illnesses have been linked to the Class II recall that USDA prompted from BSE and or h-BASE or any other strain, is just that BS. the USDA knows PERFECTLY WELL that no one would get sick right off the bat from mad cow disease. Every parent out there should be demanding answers, not these same lies. THE USDA should follow every single child that consumed any of these products for the rest of there lives. there is no way out of it now. the product is gone, consumed, and these kids, the elderly, and most everybody in between have been exposed. non-ambulatory i.e. DOWNERS are the most likely to have a Transmissible Spongiform Encephalopathy. WE know it's here, we know why the USDA et al shut down the testing, they did not want to document any more. ...TSS
Science 23 November 2001: Vol. 294. no. 5547, pp. 1726 - 1728 DOI: 10.1126/science.1066838
Reports Estimation of Epidemic Size and Incubation Time Based on Age Characteristics of vCJD in the United Kingdom
Alain-Jacques Valleron,1 Pierre-Yves Boelle,1 Robert Will,2 Jean-Yves Cesbron3
SNIP...
The distribution of the vCJD incubation period that best fits the data within the framework of our model has a mean of 16.7 years, with a standard deviation of 2.6 years. The 95% upper percentile of this distribution is 21.4 years. The 95% confidence interval (CI) of the estimates of the mean and standard deviation is relatively narrow: The 95% CI for the estimate of the mean incubation period is 12.4 to 23.2 years, and the 95% CI of the standard deviation is 0.9 to 8 years (10). The decrease in susceptibility to infection in exposed subjects older than 15 years, as estimated from the parameter , was found to be very sharp: 16% per year of age (CI: 12 to 23%). This means that, under the best fitting hypothesis, an individual aged 20 years in 1981 had 55% less risk of becoming infected than a child aged 15 years (99.9% for an individual aged 70).
http://www.sciencemag.org/
NOW, the price of poker in the USA may be shorter, due to the fact the strain of mad cow disease in the USA is more virulent to humans, thus, the incubation period, for the same titre log of infectivity, via same route and source, might be faster. ...TSS
Communicated by: Terry S. Singeltary Sr.
[In submitting these data, Terry S. Singeltary Sr. draws attention to the steady increase in the "type unknown" category, which, according to their definition, comprises cases in which vCJD could be excluded. The total of 26 cases for the current year (2007) is disturbing, possibly symptomatic of the circulation of novel agents.
Characterization of these agents should be given a high priority. - Mod.CP]
[see also:
snip...
************************************************************ Become a ProMED-mail Premium Subscriber at
************************************************************ Visit ProMED-mail's web site at .
http://pro-med.blogspot.com/2007/11/proahedr-prion-disease-update-2007-07.html
SEE STEADY INCREASE IN SPORADIC CJD IN THE USA FROM 1997 TO 2006. SPORADIC CJD CASES TRIPLED, with phenotype of 'UNKNOWN' strain growing. ...
http://www.cjdsurveillance.com/resources-casereport.html
There is a growing number of human CJD cases, and they were presented last week in San Francisco by Luigi Gambatti(?) from his CJD surveillance collection.
He estimates that it may be up to 14 or 15 persons which display selectively SPRPSC and practically no detected RPRPSC proteins.
http://www.fda.gov/ohrms/dockets/ac/06/transcripts/1006-4240t1.htm
http://www.fda.gov/ohrms/dockets/ac/06/transcripts/2006-4240t1.pdf
PLEASE SEE !
P02.35 Molecular Features of the Protease-resistant Prion Protein (PrPres) in H- type BSE
Biacabe, A-G1; Jacobs, JG2; Gavier-Widén, D3; Vulin, J1; Langeveld, JPM2; Baron, TGM1 1AFSSA, France; 2CIDC-Lelystad, Netherlands; 3SVA, Sweden
Western blot analyses of PrPres accumulating in the brain of BSE- infected cattle have demonstrated 3 different molecular phenotypes regarding to the apparent molecular masses and glycoform ratios of PrPres bands. We initially described isolates (H-type BSE) essentially characterized by higher PrPres molecular mass and decreased levels of the diglycosylated PrPres band, in contrast to the classical type of BSE. This type is also distinct from another BSE phenotype named L-type BSE, or also BASE (for Bovine Amyloid Spongiform Encephalopathy), mainly characterized by a low representation of the diglycosylated PrPres band as well as a lower PrPres molecular mass. Retrospective molecular studies in France of all available BSE cases older than 8 years old and of part of the other cases identified since the beginning of the exhaustive surveillance of the disease in 20001 allowed to identify 7 H- type BSE cases, among 594 BSE cases that could be classified as classical, L- or H-type BSE. By Western blot analysis of H-type PrPres, we described a remarkable specific feature with antibodies raised against the C-terminal region of PrP that demonstrated the existence of a more C-terminal cleaved form of PrPres (named PrPres#2 ), in addition to the usual PrPres form (PrPres #1). In the unglycosylated form, PrPres #2 migrates at about 14 kDa, compared to 20 kDa for PrPres #1. The proportion of the PrPres#2 in cattle seems to by higher compared to the PrPres#1. Furthermore another PK–resistant fragment at about 7 kDa was detected by some more N-terminal antibodies and presumed to be the result of cleavages of both N- and C- terminal parts of PrP. These singular features were maintained after transmission of the disease to C57Bl/6 mice. The identification of these two additional PrPres fragments (PrPres #2 and 7kDa band) *** reminds features reported respectively in sporadic Creutzfeldt-Jakob disease and in Gerstmann-Sträussler-Scheinker (GSS) syndrome in humans.
FC5.5.1 BASE Transmitted to Primates and MV2 sCJD Subtype Share PrP27-30 and PrPSc C-terminal Truncated Fragments
Zanusso, G1; Commoy, E2; Fasoli, E3; Fiorini, M3; Lescoutra, N4; Ruchoux, MM4; Casalone, C5; Caramelli, M5; Ferrari, S3; Lasmezas, C6; Deslys, J-P4; Monaco, S3 1University of Verona, of Neurological and Visual Sciences, Italy; 2CEA, IMETI/SEPIA, France; 3University of Verona, Neurological and Visual Sciences, Italy; 4IMETI/SEPIA, France; 5IZSPLVA, Italy; 6The Scripps Research Insitute, USA
The etiology of sporadic Creutzfeldt-Jakob disease (sCJD), the most frequent human prion disease, remains still unknown. The marked disease phenotype heterogeneity observed in sCJD is thought to be influenced by the type of proteinase K- resistant prion protein, or PrPSc (type 1 or type 2 according to the electrophoretic mobility of the unglycosylated backbone), and by the host polymorphic Methionine/Valine (M/V) codon 129 of the PRNP. By using a two-dimensional gel electrophoresis (2D-PAGE) and imunoblotting we previously showed that in sCJD, in addition to the PrPSc type, distinct PrPSc C-terminal truncated fragments (CTFs) correlated with different sCJD subtypes. Based on the combination of CTFs and PrPSc type, we distinguished three PrPSc patterns: (i) the first was observed in sCJD with PrPSc type 1 of all genotypes,;
(ii) the second was found in M/M-2 (cortical form); (iii) the third in amyloidogenic M/V- 2 and V/V-2 subtypes (Zanusso et al., JBC 2004) . Recently, we showed that sCJD subtype M/V-2 shared molecular and pathological features with an atypical form of BSE, named BASE, thus suggesting a potential link between the two conditions. This connection was further confirmed after 2D-PAGE analysis, which showed an identical PrPSc signature, including the biochemical pattern of CTFs. To pursue this issue, we obtained brain homogenates from Cynomolgus macaques intracerebrally inoculated with brain homogenates from BASE. Samples were separated by using a twodimensional electrophoresis (2D-PAGE) followed by immunoblotting. We here show that the PrPSc pattern obtained in infected primates is identical to BASE and sCJD MV-2 subtype. *** These data strongly support the link, or at least a common ancestry, between a sCJD subtype and BASE.
This work was supported by Neuroprion (FOOD-CT-2004-506579)
************************************************** *****
USA MAD COW CASES IN ALABAMA AND TEXAS
***PLEASE NOTE***
USA BASE CASE, (ATYPICAL BSE), AND OR TSE (whatever they are calling it today), please note that both the ALABAMA COW, AND THE TEXAS COW,both were ''H-TYPE'', personal communication Detwiler et al Wednesday, August 22, 2007 11:52 PM. ...TSS
http://lists.iatp.org/listarchive/archive.cfm?listID=147&startrow=1081
Tuesday, November 17, 2009
SEAC NEW RESULTS ON IDIOPATHIC BRAINSTEM NEURONAL CHROMATOLYSIS (IBNC) FROM THE VETERINARY LABORATORIES AGENCY (VLA) SEAC 103/1
http://bse-atypical.blogspot.com/2009/11/seac-new-results-on-idiopathic.html
2009 UPDATE ON ALABAMA AND TEXAS MAD COWS 2005 and 2006
http://bse-atypical.blogspot.com/2006/08/bse-atypical-texas-and-alabama-update.html
Monday, October 19, 2009
Atypical BSE, BSE, and other human and animal TSE in North America Update October 2009
http://bse-atypical.blogspot.com/2009/10/atypical-bse-bse-and-other-human-and.html
Tuesday, November 10, 2009
Surveillance On the Bovine Spongiform Encephalopathy and rabies in Taiwan and USA
http://usdavskorea.blogspot.com/2009/11/surveillance-on-bovine-spongiform.html
**************************************************
FC5.5.2 Transmission of Italian BSE and BASE Isolates in Cattle Results into a Typical BSE Phenotype and a Muscle Wasting Disease
Zanusso, G1; Lombardi, G2; Casalone, C3; D’Angelo, A4; Gelmetti, D2; Torcoli, G2; Barbieri, I2; Corona, C3; Fasoli, E1; Farinazzo, A1; Fiorini, M1; Gelati, M1; Iulini, B3; Tagliavini, F5; Ferrari, S1; Monaco, S1; Caramelli, M3; Capucci, L2 1University of Verona, Neurological and Visual Sciences, Italy; 2IZSLER, Italy; 3IZSPLVA, Italy; 4University of Turin, Animal Pathology, Italy; 5Isituto Carlo Besta, Italy
The clinical phenotype of bovine spongiform encephalopathy has been extensively reported in early accounts of the disorder. Following the introduction of statutory active surveillance, almost all BSE cases have been diagnosed on a pathological/molecular basis, in a pre-symptomatic clinical stage. In recent years, the active surveillance system has uncovered atypical BSE cases, which are characterized by distinct conformers of the PrPSc, named high-type (BSE-H) and low-type (BSE-L), whose clinicopathological phenotypes remain unknown. We recently reported two Italian atypical cases with a PrPSc type similar to BSE-L, pathologically characterized by PrP amyloid plaques. Experimental transmission to TgBov mice has recently disclosed that BASE is caused by a distinct prion strain which is extremely virulent. A major limitation of transmission studies to mice is the lack of reliable information on clinical phenotype of BASE in its natural host. In the present study, we experimentally infected Fresian/Holstein and Alpine/Brown cattle with Italian BSE and BASE isolates by i.c. route. BASE infected cattle showed survival times significantly shorter than BSE, a finding more readily evident in Fresian/Holstein, and in keeping with previous observations in TgBov mice. Clinically, BSE-infected cattle developed a disease phenotype highly comparable with that described in field BSE cases and in experimentally challenged cattle. On the contrary, BASE-inoculated cattle developed an amyotrophic disorder accompanied by mental dullness. The molecular and neuropathological profiles, including PrP deposition pattern, closely matched those observed in the original cases. This study further confirms that BASE is caused by a distinct prion isolate and discloses a novel disease phenotype in cattle, closely resembling the phenotype previous reported in scrapie-inoculated cattle *** and in some subtypes of inherited and sporadic Creutzfeldt-Jakob disease.
Oral Abstracts 14
snip...
P04.27
Experimental BSE Infection of Non-human Primates: Efficacy of the Oral Route
Holznagel, E1; Yutzy, B1; Deslys, J-P2; Lasmézas, C2; Pocchiari, M3; Ingrosso, L3; Bierke, P4; Schulz-Schaeffer, W5; Motzkus, D6; Hunsmann, G6; Löwer, J1 1Paul-Ehrlich-Institut, Germany; 2Commissariat à l´Energie Atomique, France; 3Instituto Superiore di Sanità, Italy; 4Swedish Institute for Infectious Disease control, Sweden; 5Georg August University, Germany; 6German Primate Center, Germany
Background:
In 2001, a study was initiated in primates to assess the risk for humans to contract BSE through contaminated food. For this purpose, BSE brain was titrated in cynomolgus monkeys.
Aims:
The primary objective is the determination of the minimal infectious dose (MID50) for oral exposure to BSE in a simian model, and, by in doing this, to assess the risk for humans. Secondly, we aimed at examining the course of the disease to identify possible biomarkers.
Methods:
Groups with six monkeys each were orally dosed with lowering amounts of BSE brain: 16g, 5g, 0.5g, 0.05g, and 0.005g. In a second titration study, animals were intracerebrally (i.c.) dosed (50, 5, 0.5, 0.05, and 0.005 mg).
Results:
In an ongoing study, a considerable number of high-dosed macaques already developed simian vCJD upon oral or intracerebral exposure or are at the onset of the clinical phase. However, there are differences in the clinical course between orally and intracerebrally infected animals that may influence the detection of biomarkers.
Conclusions:
Simian vCJD can be easily triggered in cynomolgus monkeys on the oral route using less than 5 g BSE brain homogenate. The difference in the incubation period between 5 g oral and 5 mg i.c. is only 1 year (5 years versus 4 years). However, there are rapid progressors among orally dosed monkeys that develop simian v CJD as fast as intracerebrally inoculated animals.
The work referenced was performed in partial fulfilment of the study “BSE in primates“ supported by the EU (QLK1-2002-01096).
http://www.prion2007.com/pdf/Prion%20Book%20of%20Abstracts.pdf
Subject: Aspects of the Cerebellar Neuropathology in Nor98
Date: September 26, 2007 at 4:06 pm PST
P03.141
Aspects of the Cerebellar Neuropathology in Nor98
Gavier-Widén, D1; Benestad, SL2; Ottander, L1; Westergren, E1 1National Veterinary Insitute, Sweden; 2National Veterinary Institute, Norway
Nor98 is a prion disease of old sheep and goats. This atypical form of scrapie was first described in Norway in 1998. Several features of Nor98 were shown to be different from classical scrapie including the distribution of disease associated prion protein (PrPd) accumulation in the brain. The cerebellum is generally the most affected brain area in Nor98. The study here presented aimed at adding information on the neuropathology in the cerebellum of Nor98 naturally affected sheep of various genotypes in Sweden and Norway. A panel of histochemical and immunohistochemical (IHC) stainings such as IHC for PrPd, synaptophysin, glial fibrillary acidic protein, amyloid, and cell markers for phagocytic cells were conducted. The type of histological lesions and tissue reactions were evaluated. The types of PrPd deposition were characterized. The cerebellar cortex was regularly affected, even though there was a variation in the severity of the lesions from case to case. Neuropil vacuolation was more marked in the molecular layer, but affected also the granular cell layer. There was a loss of granule cells. Punctate deposition of PrPd was characteristic. It was morphologically and in distribution identical with that of synaptophysin, suggesting that PrPd accumulates in the synaptic structures. PrPd was also observed in the granule cell layer and in the white matter. *** The pathology features of Nor98 in the cerebellum of the affected sheep showed similarities with those of sporadic Creutzfeldt-Jakob disease in humans.
http://www.prion2007.com/pdf/Prion%20Book%20of%20Abstracts.pdf
Wednesday, July 1, 2009
Nor98 scrapie identified in the United States J Vet Diagn Invest 21:454-463 (2009)
http://nor-98.blogspot.com/2009/07/nor98-scrapie-identified-in-united.html
full text ;
ATYPICAL NOR-98 SCRAPIE LOCATION UPDATE ON 5 DOCUMENTED CASES THIS YEAR ;
The flocks of origin are WY, CO, CA, IN, and MN.
personal communication USDA et al. ...TSS
http://nor-98.blogspot.com/
ANIMAL HEALTH REPORT 2006 (BSE h-BASE EVENT IN ALABAMA, Scrapie, and CWD)
http://animalhealthreport2006.blogspot.com/
CREUTZFELDT JAKOB DISEASE MAD COW BASE UPDATE USA
http://cjdmadcowbaseoct2007.blogspot.com/
CREUTZFELDT JAKOB DISEASE MAD COW BASE UPDATE USA
http://cjdmadcowbaseoct2007.blogspot.com/2008/02/evaluation-of-human-transmission-risk.html
Friday, February 8, 2008
Creutzfeldt Jakob Disease Delaware UPDATE
http://cjdmadcowbaseoct2007.blogspot.com/2008/02/creutzfeldt-jakob-disease-delaware.html
CJD TEXAS
http://cjdtexas.blogspot.com/
Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States
http://cjdusa.blogspot.com/
Creutzfeldt Jakob Disease
http://creutzfeldt-jakob-disease.blogspot.com/
Creutzfeldt-Jakob Disease, Prion Protein Gene Codon 129VV, and a Novel PrPSc Type in a Young British Woman
http://creutzfeldt-jakob-disease.blogspot.com/2008/01/creutzfeldt-jakob-disease-prion-protein.html
Friday, January 11, 2008
CJD HUMAN TSE REPORT UK, USA, CANADA, and Mexico JANUARY 2008
http://cjdmadcowbaseoct2007.blogspot.com/2008/01/cjd-human-tse-report-uk-usa-canada-and.html
Sunday, December 16, 2007
Risk factors for sporadic Creutzfeldt-Jakob disease
Published Online: 11 Dec 2007
http://creutzfeldt-jakob-disease.blogspot.com/2007/12/risk-factors-for-sporadic-creutzfeldt.html
http://creutzfeldt-jakob-disease.blogspot.com/2008/01/risk-factors-for-sporadic-creutzfeldt.html
Monday, December 31, 2007
Risk Assessment of Transmission of Sporadic Creutzfeldt-Jakob Disease in Endodontic Practice in Absence of Adequate Prion Inactivation
http://creutzfeldt-jakob-disease.blogspot.com/2007/12/risk-assessment-of-transmission-of.html
Friday, January 25, 2008
January 2008 Update on Feed Enforcement Activities to Limit the Spread of BSE
http://madcowspontaneousnot.blogspot.com/2008/01/january-2008-update-on-feed-enforcement.html
http://madcowspontaneousnot.blogspot.com/
BSE BASE MAD COW TESTING TEXAS, USA, AND CANADA
http://madcowtesting.blogspot.com/
Sunday, February 17, 2008 Release No. 0046.08
Statement by Secretary of Agriculture Ed Schafer Regarding Hallmark/Westland Meat Packing Company Two Year Product Recall
USDA Press Office (202) 720-4623
http://cjdmadcowbaseoct2007.blogspot.com/2008/02/release-no-004608-statement-by.html
NON-AMBULATORY (DOWNER) COW
http://downercattle.blogspot.com/
Wednesday, February 27, 2008
BEEF RECALL NATIONWIDE - SCHOOL LUNCH PROGRAM UPDATE
http://downercattle.blogspot.com/2008/02/beef-recall-nationwide-school-lunch.html
CJD QUESTIONNAIRE
http://cjdquestionnaire.blogspot.com/
Specified Risk Material SRM
http://madcowspontaneousnot.blogspot.com/2008/02/specified-risk-materials-srm.html
Subject: [Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk Materials for Human Food and Requirements for the Disposition of Non-Ambulatory Disabled Cattle
Greetings FSIS,
I would kindly like to submit the following to [Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk Materials for Human Food and Requirements for the Disposition of Non-Ambulatory Disabled Cattle
THE BSE/TSE SUB CLINICAL
Non-Ambulatory Disabled Cattle Broken bones and such may be the first signs of a sub clinical BSE/TSE Non-Ambulatory Disabled Cattle ;
SUB CLINICAL PRION INFECTION MRC-43-00 Issued: Monday, 28 August 2000
NEW EVIDENCE OF SUB-CLINICAL PRION INFECTION: IMPORTANT RESEARCH FINDINGS RELEVANT TO CJD AND BSE
A team of researchers led by Professor John Collinge at the Medical Research Council Prion Unit1 report today in the Proceedings of the National Academy of Sciences, on new evidence for the existence of a ?sub-clinical? form of BSE in mice which was unknown until now. The scientists took a closer look at what is known as the ?species barrier? - the main protective factor which
limits the ability of prions2 to jump from one species to infect another. They found the mice had a ?sub-clinical? form of disease where they carried high levels of infectivity but did not develop the clinical disease during their normal lifespan. The idea that individuals can carry a disease and show no clinical symptoms is not new. It is commonly seen in conventional infectious diseases. Researchers tried to infect laboratory mice with hamster prions3 called Sc237 and found that the mice showed no apparent signs of disease. However, on closer inspection they found that the mice had high levels of mouse prions in their brains. This was surprising because it has always been assumed that hamster prions could not cause the disease in mice, even when injected directly into the brain. In addition the researchers showed that this new sub-clinical infection could be easily passed on when injected into healthy mice and hamsters. The height of the species barrier varies widely between different combinations of animals and also varies with the type or strain of prions. While some barriers are quite small (for instance BSE easily infects mice), other combinations of strain and species show a seemingly impenetrable barrier. Traditionally, the particular barrier studied here was assumed to be robust. Professor John Collinge said: "These results have a number of important implications. They suggest that we should re-think how we measure species barriers in the laboratory, and that we should not assume that just because one species appears resistant to a strain of prions they have been exposed to, that they do not silently carry the infection.
This research raises the possibility, which has been mentioned before, that apparently healthy cattle could harbour, but never show signs of, BSE. "This is a timely and unexpected result, increasing what we know about prion disease. These new findings have important implications for those researching prion disease, those responsible for preventing infected material getting into the food chain and for those considering how best to safeguard health and reduce the risk that theoretically, prion disease could be contracted through medical and surgical procedures."
ISSUED FRIDAY 25 AUGUST UNDER EMBARGO. PLEASE NOTE THAT THE EMBARGO IS SET BY THE JOURNAL.
http://www.mrc.ac.uk/index/public_interest/public-press_office/public-press_releases_2000/public-mrc-43-00.htm
SNIP...
https://web01.aphis.usda.gov/regpublic.nsf/0/eff9eff1f7c5cf2b87256ecf000df08d?OpenDocument
PNAS August 29, 2000 vol. 97 no. 18 10248-10253 Neurobiology
Species-barrier-independent prion replication in apparentlyresistant species
Andrew F. Hill*, Susan Joiner*, Jackie Linehan*, Melanie Desbruslais*, Peter L. Lantos , and John Collinge*,
SEE FULL TEXT 17 pages ;
http://www.fsis.usda.gov/OPPDE/Comments/03-025IFA/03-025IFA-2.pdf
Terry S. Singeltary Sr. P.O. Box 42 Bacliff, Texas USA 77518
CJD QUESTIONNAIRE
http://cjdquestionnaire.blogspot.com/
Specified Risk Material SRM
http://madcowspontaneousnot.blogspot.com/2008/02/specified-risk-materials-srm.html
TSS
Wednesday, February 27, 2008
BEEF RECALL NATIONWIDE - SCHOOL LUNCH PROGRAM UPDATE
http://downercattle.blogspot.com/2008/02/beef-recall-nationwide-school-lunch.html
Beef - Westland/Hallmark Recall OF BEEF WITH DEADSTOCK DOWNER COWS, THE MOST HIGH RISK CATTLE FOR BSE/TSE AKA MAD COW DISEASE
Additional Products Listing 5-20-08
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
TOTAL DISTRIBUTION LIST
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20All%20Dist042008.pdf
ADDITIONAL PRODUCTS CONTAINING RECALLED BEEF
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
SEE FULL LIST OF ALL RECALLED SUSPECT DEAD STOCK DOWNER COW PRODUCTS HERE ;
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
Beef - Westland/Hallmark Recall OF BEEF WITH DEADSTOCK DOWNER COWS, THE MOST HIGH RISK CATTLE FOR BSE/TSE AKA MAD COW DISEASE
Additional Products Listing 5-20-08
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
TOTAL DISTRIBUTION LIST
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20All%20Dist042008.pdf
ADDITIONAL PRODUCTS CONTAINING RECALLED BEEF
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
SEE FULL LIST OF ALL RECALLED SUSPECT DEAD STOCK DOWNER COW PRODUCTS HERE ;
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
>>>In the papers, the government alleges the meatpacking plant slaughtered and processed downer cows for nearly four years — from January 2004 to September 2007 — <<<
95%) downer or dead dairy cattle and a few horses. Sheep had never been fed.
We believe that these findings may indicate the presence of a previously unrecognized scrapie-like disease in cattle and wish to alert dairy practitioners to this possibility.
snip...
PROCEEDINGS OF THE SEVENTH ANNUAL WESTERN CONFERENCE FOR FOOD ANIMAL VETERINARY MEDICINE, University of Arizona, March 17-19, 1986
http://web.archive.org/web/20030331063559/http://www.bseinquiry.gov.uk/files/mb/m09a/tab01.pdf
http://web.archive.org/web/20030516051623/http://www.bseinquiry.gov.uk/files/mb/m09/tab05.pdf
IN CONFIDENCE
PERCEPTIONS OF UNCONVENTIONAL SLOW VIRUS DISEASES OF ANIMALS IN THE USA
http://collections.europarchive.org/tna/20080102193705/http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf
TSS
California lists possible recipients of recalled Hallmark beef
By Janie Gabbett on 3/5/2008 for Meatingplace.com
It took the California Department of Public Health 120 pages to list nearly 3,000 restaurants and other businesses in the state that may have received some of the two years' worth of beef that Hallmark/Westland Meat Co. recalled last month.
The list, viewable on www.cdph.ca.gov, could be over the top, however. Some food distributors told Nation's Restaurant News they gave California officials their entire customer list rather than a roster of the restaurants that purchased the recalled beef.
The agency has also posted a list of products recalled by companies including ConAgra Foods, Kirkland, General Mills, Nestle and Richwood Meat because they could have contained meat involved in the recall.
No illnesses have been linked to the Class II recall that USDA prompted after videos shot by the Humane Society of the United States revealed animal handling of downer cows that were out of compliance with USDA's animal welfare rules.
Under current federal rules, retailers of recalled products are not revealed. California law, however, allows the state to reveal the names of businesses that may be selling the food in question. Some consumer groups and U.S. legislators have been calling for federal rule changes to allow such listings nationwide.
http://meatingplace.com/MembersOnly/webNews/details.aspx?item=19962
>>>No illnesses have been linked to the Class II recall that USDA prompted after videos shot by the Humane Society of the United States revealed animal handling of downer cows that were out of compliance with USDA's animal welfare rules. <<<
href="http://dhs.ca.gov/fdb/local/PDF/WestlandRecallRetailDistributionConsolidatedForWeb2-29-08.PDF">http://dhs.ca.gov/fdb/local/PDF/WestlandRecallRetailDistributionConsolidatedForWeb2-29-08.PDF
Additional Products Containing Westland Recalled Beef
http://dhs.ca.gov/fdb/local/PDF/AdditionalProductsContainingWestlandRecalledBeef2-29-08.PDF
IF the USDA and the FDA et al were not in bed with the industry so much, they would come clean with the rest of the states, and produce a list for the public from each state as was done in California. THAT'S just one state folks. nope, all the BSe about how No illnesses have been linked to the Class II recall that USDA prompted from BSE and or h-BASE or any other strain, is just that BS. the USDA knows PERFECTLY WELL that no one would get sick right off the bat from mad cow disease. Every parent out there should be demanding answers, not these same lies. THE USDA should follow every single child that consumed any of these products for the rest of there lives. there is no way out of it now. the product is gone, consumed, and these kids, the elderly, and most everybody in between have been exposed. non-ambulatory i.e. DOWNERS are the most likely to have a Transmissible Spongiform Encephalopathy. WE know it's here, we know why the USDA et al shut down the testing, they did not want to document any more. ...TSS
Science 23 November 2001: Vol. 294. no. 5547, pp. 1726 - 1728 DOI: 10.1126/science.1066838
Reports Estimation of Epidemic Size and Incubation Time Based on Age Characteristics of vCJD in the United Kingdom
Alain-Jacques Valleron,1 Pierre-Yves Boelle,1 Robert Will,2 Jean-Yves Cesbron3
SNIP...
The distribution of the vCJD incubation period that best fits the data within the framework of our model has a mean of 16.7 years, with a standard deviation of 2.6 years. The 95% upper percentile of this distribution is 21.4 years. The 95% confidence interval (CI) of the estimates of the mean and standard deviation is relatively narrow: The 95% CI for the estimate of the mean incubation period is 12.4 to 23.2 years, and the 95% CI of the standard deviation is 0.9 to 8 years (10). The decrease in susceptibility to infection in exposed subjects older than 15 years, as estimated from the parameter , was found to be very sharp: 16% per year of age (CI: 12 to 23%). This means that, under the best fitting hypothesis, an individual aged 20 years in 1981 had 55% less risk of becoming infected than a child aged 15 years (99.9% for an individual aged 70).
http://www.sciencemag.org/
NOW, the price of poker in the USA may be shorter, due to the fact the strain of mad cow disease in the USA is more virulent to humans, thus, the incubation period, for the same titre log of infectivity, via same route and source, might be faster. ...TSS
Communicated by: Terry S. Singeltary Sr.
[In submitting these data, Terry S. Singeltary Sr. draws attention to the steady increase in the "type unknown" category, which, according to their definition, comprises cases in which vCJD could be excluded. The total of 26 cases for the current year (2007) is disturbing, possibly symptomatic of the circulation of novel agents.
Characterization of these agents should be given a high priority. - Mod.CP]
[see also:
snip...
************************************************************ Become a ProMED-mail Premium Subscriber at
************************************************************ Visit ProMED-mail's web site at .
http://pro-med.blogspot.com/2007/11/proahedr-prion-disease-update-2007-07.html
SEE STEADY INCREASE IN SPORADIC CJD IN THE USA FROM 1997 TO 2006. SPORADIC CJD CASES TRIPLED, with phenotype of 'UNKNOWN' strain growing. ...
http://www.cjdsurveillance.com/resources-casereport.html
There is a growing number of human CJD cases, and they were presented last week in San Francisco by Luigi Gambatti(?) from his CJD surveillance collection.
He estimates that it may be up to 14 or 15 persons which display selectively SPRPSC and practically no detected RPRPSC proteins.
http://www.fda.gov/ohrms/dockets/ac/06/transcripts/1006-4240t1.htm
http://www.fda.gov/ohrms/dockets/ac/06/transcripts/2006-4240t1.pdf
PLEASE SEE !
P02.35 Molecular Features of the Protease-resistant Prion Protein (PrPres) in H- type BSE
Biacabe, A-G1; Jacobs, JG2; Gavier-Widén, D3; Vulin, J1; Langeveld, JPM2; Baron, TGM1 1AFSSA, France; 2CIDC-Lelystad, Netherlands; 3SVA, Sweden
Western blot analyses of PrPres accumulating in the brain of BSE- infected cattle have demonstrated 3 different molecular phenotypes regarding to the apparent molecular masses and glycoform ratios of PrPres bands. We initially described isolates (H-type BSE) essentially characterized by higher PrPres molecular mass and decreased levels of the diglycosylated PrPres band, in contrast to the classical type of BSE. This type is also distinct from another BSE phenotype named L-type BSE, or also BASE (for Bovine Amyloid Spongiform Encephalopathy), mainly characterized by a low representation of the diglycosylated PrPres band as well as a lower PrPres molecular mass. Retrospective molecular studies in France of all available BSE cases older than 8 years old and of part of the other cases identified since the beginning of the exhaustive surveillance of the disease in 20001 allowed to identify 7 H- type BSE cases, among 594 BSE cases that could be classified as classical, L- or H-type BSE. By Western blot analysis of H-type PrPres, we described a remarkable specific feature with antibodies raised against the C-terminal region of PrP that demonstrated the existence of a more C-terminal cleaved form of PrPres (named PrPres#2 ), in addition to the usual PrPres form (PrPres #1). In the unglycosylated form, PrPres #2 migrates at about 14 kDa, compared to 20 kDa for PrPres #1. The proportion of the PrPres#2 in cattle seems to by higher compared to the PrPres#1. Furthermore another PK–resistant fragment at about 7 kDa was detected by some more N-terminal antibodies and presumed to be the result of cleavages of both N- and C- terminal parts of PrP. These singular features were maintained after transmission of the disease to C57Bl/6 mice. The identification of these two additional PrPres fragments (PrPres #2 and 7kDa band) *** reminds features reported respectively in sporadic Creutzfeldt-Jakob disease and in Gerstmann-Sträussler-Scheinker (GSS) syndrome in humans.
FC5.5.1 BASE Transmitted to Primates and MV2 sCJD Subtype Share PrP27-30 and PrPSc C-terminal Truncated Fragments
Zanusso, G1; Commoy, E2; Fasoli, E3; Fiorini, M3; Lescoutra, N4; Ruchoux, MM4; Casalone, C5; Caramelli, M5; Ferrari, S3; Lasmezas, C6; Deslys, J-P4; Monaco, S3 1University of Verona, of Neurological and Visual Sciences, Italy; 2CEA, IMETI/SEPIA, France; 3University of Verona, Neurological and Visual Sciences, Italy; 4IMETI/SEPIA, France; 5IZSPLVA, Italy; 6The Scripps Research Insitute, USA
The etiology of sporadic Creutzfeldt-Jakob disease (sCJD), the most frequent human prion disease, remains still unknown. The marked disease phenotype heterogeneity observed in sCJD is thought to be influenced by the type of proteinase K- resistant prion protein, or PrPSc (type 1 or type 2 according to the electrophoretic mobility of the unglycosylated backbone), and by the host polymorphic Methionine/Valine (M/V) codon 129 of the PRNP. By using a two-dimensional gel electrophoresis (2D-PAGE) and imunoblotting we previously showed that in sCJD, in addition to the PrPSc type, distinct PrPSc C-terminal truncated fragments (CTFs) correlated with different sCJD subtypes. Based on the combination of CTFs and PrPSc type, we distinguished three PrPSc patterns: (i) the first was observed in sCJD with PrPSc type 1 of all genotypes,;
(ii) the second was found in M/M-2 (cortical form); (iii) the third in amyloidogenic M/V- 2 and V/V-2 subtypes (Zanusso et al., JBC 2004) . Recently, we showed that sCJD subtype M/V-2 shared molecular and pathological features with an atypical form of BSE, named BASE, thus suggesting a potential link between the two conditions. This connection was further confirmed after 2D-PAGE analysis, which showed an identical PrPSc signature, including the biochemical pattern of CTFs. To pursue this issue, we obtained brain homogenates from Cynomolgus macaques intracerebrally inoculated with brain homogenates from BASE. Samples were separated by using a twodimensional electrophoresis (2D-PAGE) followed by immunoblotting. We here show that the PrPSc pattern obtained in infected primates is identical to BASE and sCJD MV-2 subtype. *** These data strongly support the link, or at least a common ancestry, between a sCJD subtype and BASE.
This work was supported by Neuroprion (FOOD-CT-2004-506579)
************************************************** *****
USA MAD COW CASES IN ALABAMA AND TEXAS
***PLEASE NOTE***
USA BASE CASE, (ATYPICAL BSE), AND OR TSE (whatever they are calling it today), please note that both the ALABAMA COW, AND THE TEXAS COW,both were ''H-TYPE'', personal communication Detwiler et al Wednesday, August 22, 2007 11:52 PM. ...TSS
http://lists.iatp.org/listarchive/archive.cfm?listID=147&startrow=1081
Tuesday, November 17, 2009
SEAC NEW RESULTS ON IDIOPATHIC BRAINSTEM NEURONAL CHROMATOLYSIS (IBNC) FROM THE VETERINARY LABORATORIES AGENCY (VLA) SEAC 103/1
http://bse-atypical.blogspot.com/2009/11/seac-new-results-on-idiopathic.html
2009 UPDATE ON ALABAMA AND TEXAS MAD COWS 2005 and 2006
http://bse-atypical.blogspot.com/2006/08/bse-atypical-texas-and-alabama-update.html
Monday, October 19, 2009
Atypical BSE, BSE, and other human and animal TSE in North America Update October 2009
http://bse-atypical.blogspot.com/2009/10/atypical-bse-bse-and-other-human-and.html
Tuesday, November 10, 2009
Surveillance On the Bovine Spongiform Encephalopathy and rabies in Taiwan and USA
http://usdavskorea.blogspot.com/2009/11/surveillance-on-bovine-spongiform.html
**************************************************
FC5.5.2 Transmission of Italian BSE and BASE Isolates in Cattle Results into a Typical BSE Phenotype and a Muscle Wasting Disease
Zanusso, G1; Lombardi, G2; Casalone, C3; D’Angelo, A4; Gelmetti, D2; Torcoli, G2; Barbieri, I2; Corona, C3; Fasoli, E1; Farinazzo, A1; Fiorini, M1; Gelati, M1; Iulini, B3; Tagliavini, F5; Ferrari, S1; Monaco, S1; Caramelli, M3; Capucci, L2 1University of Verona, Neurological and Visual Sciences, Italy; 2IZSLER, Italy; 3IZSPLVA, Italy; 4University of Turin, Animal Pathology, Italy; 5Isituto Carlo Besta, Italy
The clinical phenotype of bovine spongiform encephalopathy has been extensively reported in early accounts of the disorder. Following the introduction of statutory active surveillance, almost all BSE cases have been diagnosed on a pathological/molecular basis, in a pre-symptomatic clinical stage. In recent years, the active surveillance system has uncovered atypical BSE cases, which are characterized by distinct conformers of the PrPSc, named high-type (BSE-H) and low-type (BSE-L), whose clinicopathological phenotypes remain unknown. We recently reported two Italian atypical cases with a PrPSc type similar to BSE-L, pathologically characterized by PrP amyloid plaques. Experimental transmission to TgBov mice has recently disclosed that BASE is caused by a distinct prion strain which is extremely virulent. A major limitation of transmission studies to mice is the lack of reliable information on clinical phenotype of BASE in its natural host. In the present study, we experimentally infected Fresian/Holstein and Alpine/Brown cattle with Italian BSE and BASE isolates by i.c. route. BASE infected cattle showed survival times significantly shorter than BSE, a finding more readily evident in Fresian/Holstein, and in keeping with previous observations in TgBov mice. Clinically, BSE-infected cattle developed a disease phenotype highly comparable with that described in field BSE cases and in experimentally challenged cattle. On the contrary, BASE-inoculated cattle developed an amyotrophic disorder accompanied by mental dullness. The molecular and neuropathological profiles, including PrP deposition pattern, closely matched those observed in the original cases. This study further confirms that BASE is caused by a distinct prion isolate and discloses a novel disease phenotype in cattle, closely resembling the phenotype previous reported in scrapie-inoculated cattle *** and in some subtypes of inherited and sporadic Creutzfeldt-Jakob disease.
Oral Abstracts 14
snip...
P04.27
Experimental BSE Infection of Non-human Primates: Efficacy of the Oral Route
Holznagel, E1; Yutzy, B1; Deslys, J-P2; Lasmézas, C2; Pocchiari, M3; Ingrosso, L3; Bierke, P4; Schulz-Schaeffer, W5; Motzkus, D6; Hunsmann, G6; Löwer, J1 1Paul-Ehrlich-Institut, Germany; 2Commissariat à l´Energie Atomique, France; 3Instituto Superiore di Sanità, Italy; 4Swedish Institute for Infectious Disease control, Sweden; 5Georg August University, Germany; 6German Primate Center, Germany
Background:
In 2001, a study was initiated in primates to assess the risk for humans to contract BSE through contaminated food. For this purpose, BSE brain was titrated in cynomolgus monkeys.
Aims:
The primary objective is the determination of the minimal infectious dose (MID50) for oral exposure to BSE in a simian model, and, by in doing this, to assess the risk for humans. Secondly, we aimed at examining the course of the disease to identify possible biomarkers.
Methods:
Groups with six monkeys each were orally dosed with lowering amounts of BSE brain: 16g, 5g, 0.5g, 0.05g, and 0.005g. In a second titration study, animals were intracerebrally (i.c.) dosed (50, 5, 0.5, 0.05, and 0.005 mg).
Results:
In an ongoing study, a considerable number of high-dosed macaques already developed simian vCJD upon oral or intracerebral exposure or are at the onset of the clinical phase. However, there are differences in the clinical course between orally and intracerebrally infected animals that may influence the detection of biomarkers.
Conclusions:
Simian vCJD can be easily triggered in cynomolgus monkeys on the oral route using less than 5 g BSE brain homogenate. The difference in the incubation period between 5 g oral and 5 mg i.c. is only 1 year (5 years versus 4 years). However, there are rapid progressors among orally dosed monkeys that develop simian v CJD as fast as intracerebrally inoculated animals.
The work referenced was performed in partial fulfilment of the study “BSE in primates“ supported by the EU (QLK1-2002-01096).
http://www.prion2007.com/pdf/Prion%20Book%20of%20Abstracts.pdf
Subject: Aspects of the Cerebellar Neuropathology in Nor98
Date: September 26, 2007 at 4:06 pm PST
P03.141
Aspects of the Cerebellar Neuropathology in Nor98
Gavier-Widén, D1; Benestad, SL2; Ottander, L1; Westergren, E1 1National Veterinary Insitute, Sweden; 2National Veterinary Institute, Norway
Nor98 is a prion disease of old sheep and goats. This atypical form of scrapie was first described in Norway in 1998. Several features of Nor98 were shown to be different from classical scrapie including the distribution of disease associated prion protein (PrPd) accumulation in the brain. The cerebellum is generally the most affected brain area in Nor98. The study here presented aimed at adding information on the neuropathology in the cerebellum of Nor98 naturally affected sheep of various genotypes in Sweden and Norway. A panel of histochemical and immunohistochemical (IHC) stainings such as IHC for PrPd, synaptophysin, glial fibrillary acidic protein, amyloid, and cell markers for phagocytic cells were conducted. The type of histological lesions and tissue reactions were evaluated. The types of PrPd deposition were characterized. The cerebellar cortex was regularly affected, even though there was a variation in the severity of the lesions from case to case. Neuropil vacuolation was more marked in the molecular layer, but affected also the granular cell layer. There was a loss of granule cells. Punctate deposition of PrPd was characteristic. It was morphologically and in distribution identical with that of synaptophysin, suggesting that PrPd accumulates in the synaptic structures. PrPd was also observed in the granule cell layer and in the white matter. *** The pathology features of Nor98 in the cerebellum of the affected sheep showed similarities with those of sporadic Creutzfeldt-Jakob disease in humans.
http://www.prion2007.com/pdf/Prion%20Book%20of%20Abstracts.pdf
Wednesday, July 1, 2009
Nor98 scrapie identified in the United States J Vet Diagn Invest 21:454-463 (2009)
http://nor-98.blogspot.com/2009/07/nor98-scrapie-identified-in-united.html
full text ;
ATYPICAL NOR-98 SCRAPIE LOCATION UPDATE ON 5 DOCUMENTED CASES THIS YEAR ;
The flocks of origin are WY, CO, CA, IN, and MN.
personal communication USDA et al. ...TSS
http://nor-98.blogspot.com/
ANIMAL HEALTH REPORT 2006 (BSE h-BASE EVENT IN ALABAMA, Scrapie, and CWD)
http://animalhealthreport2006.blogspot.com/
CREUTZFELDT JAKOB DISEASE MAD COW BASE UPDATE USA
http://cjdmadcowbaseoct2007.blogspot.com/
CREUTZFELDT JAKOB DISEASE MAD COW BASE UPDATE USA
http://cjdmadcowbaseoct2007.blogspot.com/2008/02/evaluation-of-human-transmission-risk.html
Friday, February 8, 2008
Creutzfeldt Jakob Disease Delaware UPDATE
http://cjdmadcowbaseoct2007.blogspot.com/2008/02/creutzfeldt-jakob-disease-delaware.html
CJD TEXAS
http://cjdtexas.blogspot.com/
Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States
http://cjdusa.blogspot.com/
Creutzfeldt Jakob Disease
http://creutzfeldt-jakob-disease.blogspot.com/
Creutzfeldt-Jakob Disease, Prion Protein Gene Codon 129VV, and a Novel PrPSc Type in a Young British Woman
http://creutzfeldt-jakob-disease.blogspot.com/2008/01/creutzfeldt-jakob-disease-prion-protein.html
Friday, January 11, 2008
CJD HUMAN TSE REPORT UK, USA, CANADA, and Mexico JANUARY 2008
http://cjdmadcowbaseoct2007.blogspot.com/2008/01/cjd-human-tse-report-uk-usa-canada-and.html
Sunday, December 16, 2007
Risk factors for sporadic Creutzfeldt-Jakob disease
Published Online: 11 Dec 2007
http://creutzfeldt-jakob-disease.blogspot.com/2007/12/risk-factors-for-sporadic-creutzfeldt.html
http://creutzfeldt-jakob-disease.blogspot.com/2008/01/risk-factors-for-sporadic-creutzfeldt.html
Monday, December 31, 2007
Risk Assessment of Transmission of Sporadic Creutzfeldt-Jakob Disease in Endodontic Practice in Absence of Adequate Prion Inactivation
http://creutzfeldt-jakob-disease.blogspot.com/2007/12/risk-assessment-of-transmission-of.html
Friday, January 25, 2008
January 2008 Update on Feed Enforcement Activities to Limit the Spread of BSE
http://madcowspontaneousnot.blogspot.com/2008/01/january-2008-update-on-feed-enforcement.html
http://madcowspontaneousnot.blogspot.com/
BSE BASE MAD COW TESTING TEXAS, USA, AND CANADA
http://madcowtesting.blogspot.com/
Sunday, February 17, 2008 Release No. 0046.08
Statement by Secretary of Agriculture Ed Schafer Regarding Hallmark/Westland Meat Packing Company Two Year Product Recall
USDA Press Office (202) 720-4623
http://cjdmadcowbaseoct2007.blogspot.com/2008/02/release-no-004608-statement-by.html
NON-AMBULATORY (DOWNER) COW
http://downercattle.blogspot.com/
Wednesday, February 27, 2008
BEEF RECALL NATIONWIDE - SCHOOL LUNCH PROGRAM UPDATE
http://downercattle.blogspot.com/2008/02/beef-recall-nationwide-school-lunch.html
CJD QUESTIONNAIRE
http://cjdquestionnaire.blogspot.com/
Specified Risk Material SRM
http://madcowspontaneousnot.blogspot.com/2008/02/specified-risk-materials-srm.html
Subject: [Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk Materials for Human Food and Requirements for the Disposition of Non-Ambulatory Disabled Cattle
Greetings FSIS,
I would kindly like to submit the following to [Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk Materials for Human Food and Requirements for the Disposition of Non-Ambulatory Disabled Cattle
THE BSE/TSE SUB CLINICAL
Non-Ambulatory Disabled Cattle Broken bones and such may be the first signs of a sub clinical BSE/TSE Non-Ambulatory Disabled Cattle ;
SUB CLINICAL PRION INFECTION MRC-43-00 Issued: Monday, 28 August 2000
NEW EVIDENCE OF SUB-CLINICAL PRION INFECTION: IMPORTANT RESEARCH FINDINGS RELEVANT TO CJD AND BSE
A team of researchers led by Professor John Collinge at the Medical Research Council Prion Unit1 report today in the Proceedings of the National Academy of Sciences, on new evidence for the existence of a ?sub-clinical? form of BSE in mice which was unknown until now. The scientists took a closer look at what is known as the ?species barrier? - the main protective factor which
limits the ability of prions2 to jump from one species to infect another. They found the mice had a ?sub-clinical? form of disease where they carried high levels of infectivity but did not develop the clinical disease during their normal lifespan. The idea that individuals can carry a disease and show no clinical symptoms is not new. It is commonly seen in conventional infectious diseases. Researchers tried to infect laboratory mice with hamster prions3 called Sc237 and found that the mice showed no apparent signs of disease. However, on closer inspection they found that the mice had high levels of mouse prions in their brains. This was surprising because it has always been assumed that hamster prions could not cause the disease in mice, even when injected directly into the brain. In addition the researchers showed that this new sub-clinical infection could be easily passed on when injected into healthy mice and hamsters. The height of the species barrier varies widely between different combinations of animals and also varies with the type or strain of prions. While some barriers are quite small (for instance BSE easily infects mice), other combinations of strain and species show a seemingly impenetrable barrier. Traditionally, the particular barrier studied here was assumed to be robust. Professor John Collinge said: "These results have a number of important implications. They suggest that we should re-think how we measure species barriers in the laboratory, and that we should not assume that just because one species appears resistant to a strain of prions they have been exposed to, that they do not silently carry the infection.
This research raises the possibility, which has been mentioned before, that apparently healthy cattle could harbour, but never show signs of, BSE. "This is a timely and unexpected result, increasing what we know about prion disease. These new findings have important implications for those researching prion disease, those responsible for preventing infected material getting into the food chain and for those considering how best to safeguard health and reduce the risk that theoretically, prion disease could be contracted through medical and surgical procedures."
ISSUED FRIDAY 25 AUGUST UNDER EMBARGO. PLEASE NOTE THAT THE EMBARGO IS SET BY THE JOURNAL.
http://www.mrc.ac.uk/index/public_interest/public-press_office/public-press_releases_2000/public-mrc-43-00.htm
SNIP...
https://web01.aphis.usda.gov/regpublic.nsf/0/eff9eff1f7c5cf2b87256ecf000df08d?OpenDocument
PNAS August 29, 2000 vol. 97 no. 18 10248-10253 Neurobiology
Species-barrier-independent prion replication in apparentlyresistant species
Andrew F. Hill*, Susan Joiner*, Jackie Linehan*, Melanie Desbruslais*, Peter L. Lantos , and John Collinge*,
SEE FULL TEXT 17 pages ;
http://www.fsis.usda.gov/OPPDE/Comments/03-025IFA/03-025IFA-2.pdf
Terry S. Singeltary Sr. P.O. Box 42 Bacliff, Texas USA 77518
CJD QUESTIONNAIRE
http://cjdquestionnaire.blogspot.com/
Specified Risk Material SRM
http://madcowspontaneousnot.blogspot.com/2008/02/specified-risk-materials-srm.html
TSS
Wednesday, February 27, 2008
BEEF RECALL NATIONWIDE - SCHOOL LUNCH PROGRAM UPDATE
http://downercattle.blogspot.com/2008/02/beef-recall-nationwide-school-lunch.html
Beef - Westland/Hallmark Recall OF BEEF WITH DEADSTOCK DOWNER COWS, THE MOST HIGH RISK CATTLE FOR BSE/TSE AKA MAD COW DISEASE
Additional Products Listing 5-20-08
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
TOTAL DISTRIBUTION LIST
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20All%20Dist042008.pdf
ADDITIONAL PRODUCTS CONTAINING RECALLED BEEF
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
SEE FULL LIST OF ALL RECALLED SUSPECT DEAD STOCK DOWNER COW PRODUCTS HERE ;
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
Beef - Westland/Hallmark Recall OF BEEF WITH DEADSTOCK DOWNER COWS, THE MOST HIGH RISK CATTLE FOR BSE/TSE AKA MAD COW DISEASE
Additional Products Listing 5-20-08
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
TOTAL DISTRIBUTION LIST
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20All%20Dist042008.pdf
ADDITIONAL PRODUCTS CONTAINING RECALLED BEEF
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
SEE FULL LIST OF ALL RECALLED SUSPECT DEAD STOCK DOWNER COW PRODUCTS HERE ;
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
>>>In the papers, the government alleges the meatpacking plant slaughtered and processed downer cows for nearly four years — from January 2004 to September 2007 — <<<
95%) downer or dead dairy cattle and a few horses. Sheep had never been fed.
We believe that these findings may indicate the presence of a previously unrecognized scrapie-like disease in cattle and wish to alert dairy practitioners to this possibility.
snip...
PROCEEDINGS OF THE SEVENTH ANNUAL WESTERN CONFERENCE FOR FOOD ANIMAL VETERINARY MEDICINE, University of Arizona, March 17-19, 1986
http://web.archive.org/web/20030331063559/http://www.bseinquiry.gov.uk/files/mb/m09a/tab01.pdf
http://web.archive.org/web/20030516051623/http://www.bseinquiry.gov.uk/files/mb/m09/tab05.pdf
IN CONFIDENCE
PERCEPTIONS OF UNCONVENTIONAL SLOW VIRUS DISEASES OF ANIMALS IN THE USA
http://collections.europarchive.org/tna/20080102193705/http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf
TSS
To the hard working employees of USDA and their untiring efforts to protect our childrens food supply
i was going through old documents/files today and ran across a 'untitled' one. opened it up, and thought it appropriate for today. please note i added to it at the bottom i.e. addendum II 2008. ...TSS
To the hard working employees of USDA and their untiring efforts to protect our food supply
Little is known and much has been written Of the deadly disease with which some have been smitten It is certainly true there have been but a few But down on the farm there is cause for alarm
It causes great stress to the CNS T’is a strain on the brain as we shall soon see The causative agent is anyone’s guess A transmissible spongiform encephalopathy
Sheep Scrapie somehow in the UK to Mad Cow Here in the US it is anyone’s guess It’s not perfectly clear how our elk and our deer Both the tame and the free got CWD
To the best of our knowledge out west at a college Where they happened to keep some deer penned with sheep They didn't know why the deer started to die Because they did not know they let the rest go
Now from Washington state comes news that’s not great Ann Veneman tells us how they have found a MAD COW The Federal Vet said she’s a “down cow” you bet But Dave Louthan the talker say’s she was a “walker”
She was grist for the mill, she went regular kill So they started to track when the test did come back But that was 2 weeks later and people had ate her The meat was consumed and the recall was doomed
Now we must remember this occurred in December Ann and Bush have no fears, they’ll have beef for New Years
addendum
There was no proper test In a plant way out west The old cow was unwell, she staggered and fell “We don’t want her” said Ronald, “she’s not for McDonald” The vet made a call and was told not to test after all
Headquarters told Lonestar “we cant send a car” “It’s too long a trip, you don’t know how to ship” No brainstem will you tender, just send her to render We don’t want a section - wait till after election
by the Bard of Bismarck, the Old Curmudgeon Earl Fairbanks DVM USDA Ret.
addendum II 2008. ...TSS
To the hard working employees of USDA and their untiring efforts to protect our childrens food supply
and who gives a fickle, if the last two were atypical, more virulent to animals and man, we'll grind em and crush em, even the stumbling and staggering ones.
those diseased, those sick, the ones injured, be quick. another shot of antibiotics or hormones, it matters not. it's profit, it's profit, look at all we got $$$
those downers, those downers, the ones that cannot stand, oh where, oh where, can they go? with the fork lift at hand, they chain em and stand, and drag them to where know one goes. we'll shock em, and poke em, even waterboard em, and then off to the children they go.
in a long case study, we'll wait and wonder, watching for every little twitch, which one of these children, will be the first to succumb, to the monster we know as the mad cow prion.
100% fatal, for those that go clinical, with no therapy there is. you wait and wonder, as the mind goes, wondering how many others might have been exposed. there is no test, without any guess, you don't care to know.
and for those that lay claim, to no one is sick, beware, beware, for these are the facts. the mad cow prion, can lay dormant before it attacks. for years and years, and even decades to come, your children, will incubate, before they might succumb.
while Washington flounders, the mad cows still wanders, the downers they continue to go, to the cattle feed, to the childrens food and on, nobody knows. from waxman, to durbin, to bush, to leahy, the lies, and promises abound, they just seem to go round and round $$$
it's a sad, sad mess i have come to know, but the downers, all the downers, off to the incinerator they must go. ...TSS 2008
Thursday, May 13, 2004
Food Safety
Failure To Test Staggering Cow May Reflect Wider Problems
Rep. Waxman raises concerns that the recent failure of USDA to test an impaired cow for BSE may not be an isolated incident, citing the failure of USDA to monitor whether cows condemned for central nervous system symptoms are actually tested for mad cow disease.
http://reform.democrats.house.gov/documents/20040607142914-86912.pdf
http://oversight.house.gov/documents/20040607142914-86912.pdf
Statement Of Senator Patrick Leahy Senate Agriculture Committee Hearing On Mad Cow Disease January 27, 2004
For years I have joined with Senator Akaka in attempting to restrict downers from the human food supply, thus I am pleased the Department reversed course and will now implement the Downed Animal Protection Act that was contained in the 2002 Farm Bill for cattle.
http://leahy.senate.gov/press/200401/012704.html
CALIFORNIA STATE CAUCUS
Briefing Report: Mad Cow Disease
2/11/2004 - For Immediate Release
Recent Actions
On December 30, 2003, United States Agriculture Secretary Ann Veneman announced additional safeguards to bolster the U.S. protection system against BSE and to further protect public health. Downer cattle and specified risk material and tissues will immediately be banned from the human food chain. If people do not eat these dangerous parts of the cow, their risk of acquiring BSE is severely reduced.
http://republican.sen.ca.gov/opeds/99/oped2091_print.asp
2008
USDA CERTIFIED NON-AMBULATORY DOWNER COW SCHOOL LUNCH PROGRAM
http://downercattle.blogspot.com/2008/02/beef-recall-nationwide-school-lunch.html
Specified Risk Material SRM
http://madcowspontaneousnot.blogspot.com/2008/02/specified-risk-materials-srm.html
Subject: [Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk Materials for Human Food and Requirements for the Disposition of Non-Ambulatory Disabled Cattle
Greetings FSIS,
I would kindly like to submit the following to [Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk Materials for Human Food and Requirements for the Disposition of Non-Ambulatory Disabled Cattle
THE BSE/TSE SUB CLINICAL
Non-Ambulatory Disabled Cattle Broken bones and such may be the first signs of a sub clinical BSE/TSE Non-Ambulatory Disabled Cattle ;
SUB CLINICAL PRION INFECTION MRC-43-00 Issued: Monday, 28 August 2000
NEW EVIDENCE OF SUB-CLINICAL PRION INFECTION: IMPORTANT RESEARCH FINDINGS RELEVANT TO CJD AND BSE
A team of researchers led by Professor John Collinge at the Medical Research Council Prion Unit1 report today in the Proceedings of the National Academy of Sciences, on new evidence for the existence of a "sub-clinical" form of BSE in mice which was unknown until now. The scientists took a closer look at what is known as the "species barrier" - the main protective factor which
limits the ability of prions2 to jump from one species to infect another. They found the mice had a "sub-clinical" form of disease where they carried high levels of infectivity but did not develop the clinical disease during their normal lifespan. The idea that individuals can carry a disease and show no clinical symptoms is not new. It is commonly seen in conventional infectious diseases. Researchers tried to infect laboratory mice with hamster prions3 called Sc237 and found that the mice showed no apparent signs of disease. However, on closer inspection they found that the mice had high levels of mouse prions in their brains. This was surprising because it has always been assumed that hamster prions could not cause the disease in mice, even when injected directly into the brain. In addition the researchers showed that this new sub-clinical infection could be easily passed on when injected into healthy mice and hamsters. The height of the species barrier varies widely between different combinations of animals and also varies with the type or strain of prions. While some barriers are quite small (for instance BSE easily infects mice), other combinations of strain and species show a seemingly impenetrable barrier. Traditionally, the particular barrier studied here was assumed to be robust. Professor John Collinge said: "These results have a number of important implications. They suggest that we should re-think how we measure species barriers in the laboratory, and that we should not assume that just because one species appears resistant to a strain of prions they have been exposed to, that they do not silently carry the infection.
This research raises the possibility, which has been mentioned before, that apparently healthy cattle could harbour, but never show signs of, BSE. "This is a timely and unexpected result, increasing what we know about prion disease. These new findings have important implications for those researching prion disease, those responsible for preventing infected material getting into the food chain and for those considering how best to safeguard health and reduce the risk that theoretically, prion disease could be contracted through medical and surgical procedures."
ISSUED FRIDAY 25 AUGUST UNDER EMBARGO. PLEASE NOTE THAT THE EMBARGO IS SET BY THE JOURNAL.
http://www.mrc.ac.uk/index/public_interest/public-press_office/public-press_releases_2000/public-mrc-43-00.htm
SNIP...
https://web01.aphis.usda.gov/regpublic.nsf/0/eff9eff1f7c5cf2b87256ecf000df08d?OpenDocument
PNAS August 29, 2000 vol. 97 no. 18 10248-10253 Neurobiology
Species-barrier-independent prion replication in apparentlyresistant species
Andrew F. Hill*, Susan Joiner*, Jackie Linehan*, Melanie Desbruslais*, Peter L. Lantos , and John Collinge*,
SEE FULL TEXT 17 pages ;
http://www.fsis.usda.gov/OPPDE/Comments/03-025IFA/03-025IFA-2.pdf
Thursday, February 21, 2008
TRANSCRIPT: Technical Briefing - Hallmark/Westland Meat Packing Company - (02/21/08)
Release No. 0054.08
http://downercattle.blogspot.com/
http://downercattle.blogspot.com/2008/02/transcript-technical-briefing.html
Sunday, February 17, 2008
Release No. 0046.08 Statement by Secretary of Agriculture Ed Schafer Regarding Hallmark/Westland Meat Packing Company Two Year Product Recall
Release No. 0046.08
Contact: USDA Press Office (202) 720-4623
http://cjdmadcowbaseoct2007.blogspot.com/2008/02/release-no-004608-statement-by.html
Geographical BSE Risk (GBR) assessments covering 2000-2006
Date : 01.08.2006
http://www.efsa.europa.eu/EFSA/Scientific_Document/GBR_assessments_table_Overview_assessed_countries_2002-2006.pdf
In this context, a word is in order about the US testing program. After the discovery of the first (imported) cow in 2003, the magnitude of testing was much increased, reaching a level of >400,000 tests in 2005 (Figure 4). Neither of the 2 more recently indigenously infected older animals with nonspecific clinical features would have been detected without such testing, and neither would have been identified as atypical without confirmatory Western blots. Despite these facts, surveillance has now been decimated to 40,000 annual tests (USDA news release no. 0255.06, July 20, 2006) and invites the accusation that the United States will never know the true status of its involvement with BSE.
http://www.cdc.gov/ncidod/EID/vol12no12/06-0965.htm
PAUL BROWN COMMENT TO ME ON THIS ISSUE
Tuesday, September 12, 2006 11:10 AM
"Actually, Terry, I have been critical of the USDA handling of the mad cow issue for some years, and with Linda Detwiler and others sent lengthy detailed critiques and recommendations to both the USDA and the Canadian Food Agency."
http://lists.iatp.org/listarchive/archive.cfm?listID=147&startrow=1081
BEEF RECALL - USA (05) ********************** A ProMED-mail post
ProMED-mail is a program of the International Society for Infectious Diseases
http://www.promedmail.org/pls/otn/f?p=2400:1001:3581618507331539::NO::F2400_P1001_BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,71607
MAD COW TESTING USA
http://madcowtesting.blogspot.com/
Wednesday, February 27, 2008 BEEF RECALL NATIONWIDE - SCHOOL LUNCH PROGRAM UPDATE
http://downercattle.blogspot.com/2008/02/beef-recall-nationwide-school-lunch.html
CJD QUESTIONNAIRE
http://cjdquestionnaire.blogspot.com/
Specified Risk Material SRM
http://madcowspontaneousnot.blogspot.com/2008/02/specified-risk-materials-srm.html
Beef - Westland/Hallmark Recall OF BEEF WITH DEADSTOCK DOWNER COWS, THE MOST HIGH RISK CATTLE FOR BSE/TSE AKA MAD COW DISEASE
Additional Products Listing 5-20-08
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
TOTAL DISTRIBUTION LIST
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20All%20Dist042008.pdf
ADDITIONAL PRODUCTS CONTAINING RECALLED BEEF
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
SEE FULL LIST OF ALL RECALLED SUSPECT DEAD STOCK DOWNER COW PRODUCTS HERE ;
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
Beef - Westland/Hallmark Recall OF BEEF WITH DEADSTOCK DOWNER COWS, THE MOST HIGH RISK CATTLE FOR BSE/TSE AKA MAD COW DISEASE
Additional Products Listing 5-20-08
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
TOTAL DISTRIBUTION LIST
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20All%20Dist042008.pdf
ADDITIONAL PRODUCTS CONTAINING RECALLED BEEF
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
SEE FULL LIST OF ALL RECALLED SUSPECT DEAD STOCK DOWNER COW PRODUCTS HERE ;
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
>>>In the papers, the government alleges the meatpacking plant slaughtered and processed downer cows for nearly four years — from January 2004 to September 2007 — <<<
>95%) downer or dead dairy cattle and a few horses. Sheep had never been fed.
PLEASE SEE ;
We believe that these findings may indicate the presence of a previously unrecognized scrapie-like disease in cattle and wish to alert dairy practitioners to this possibility.
snip...
PROCEEDINGS OF THE SEVENTH ANNUAL WESTERN CONFERENCE FOR FOOD ANIMAL VETERINARY MEDICINE, University of Arizona, March 17-19, 1986
http://web.archive.org/web/20030331063559/http://www.bseinquiry.gov.uk/files/mb/m09a/tab01.pdf
http://web.archive.org/web/20030516051623/http://www.bseinquiry.gov.uk/files/mb/m09/tab05.pdf
IN CONFIDENCE
PERCEPTIONS OF UNCONVENTIONAL SLOW VIRUS DISEASES OF ANIMALS IN THE USA
http://collections.europarchive.org/tna/20080102193705/http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf
Wednesday, August 20, 2008
Bovine Spongiform Encephalopathy Mad Cow Disease typical and atypical strains, was there a cover-up ? August 20, 2008
snip...
another question, just how long have these atypical BSE TSEs been around in the bovine ???
let's look at another case of atypical BSE in Germany way back in 1992 ;
Subject: atypical BSE reported in 1992 and conviently slaughterd and incinerated and then swept under rug for about 12 years Date: April 26, 2007 at 1:08 pm PST 1992
NEW BRAIN DISORDER
3. WHAT ABOUT REPORTS OF NEW FORM OF BSE?
THE VETERINARY RECORD HAS PUBLISHED AN ARTICLE ON A NEW BRAIN DISORDER OF CATTLE DISCOVERED THROUGH OUR CONTROL MEASURES FOR BSE. ALTHOUGH IT PRESENTS SIMILAR CLINICAL SIGNS TO BSE THERE ARE MAJOR DIFFERENCES IN THE HISTOPATHOLOGY AND INCUBATION PERIODS BETWEEN THE TWO. MUST EMPHASISE THAT THIS IS NOT BSE.
4. IS THIS NEW BRAIN DISORDER A THREAT?
WE DO NOT EVEN KNOW WHETHER THE AGENT OF THIS DISEASE IS TRANSMISSIBLE. IN ANY CASE, CASES SO FAR IDENTIFIED HAD SHOWN SIMILAR SYMPTOMS TO THOSE OF BSE, AND THEREFORE HAVE BEEN SLAUGHTERED AND INCINERATED, SO THAT IF A TRANSMISSIBLE AGENT WERE INVOLVED IT WOULD HAVE BEEN ELIMINATED. .......
http://web.archive.org/web/20030714222309/www.bseinquiry.gov.uk/files/yb/1992/10/26001001.pdf
2. The Collinge/Will dispute appears to rumble on. Dr. Collinge had told Dr. Tyrrell that Dr. Will's response to his criticism about sharing material had been ''quite unacceptable'' (in spite of it's apparently conciliatory tone). Apparently Professor Allen was now going to try and arrange a meeting to resolve the dispute. No action here for MAFF, although Mr. Murray may be interested.
3. Dr. Tyrrell regretted that the Committee had not seen the article on BBD. However he felt that for the time being NO specific action was called for. The most important need was to consider the possibility that the condition might be transmissible. As we have discussed, I suggested that we might circulate a paper to the members of the committee giving our appreciation of this condition (and perhaps of other non-BSE neurological conditions that had been identified in negative cases) and of any necessary follow up action. IF any Committee member felt strongly about this, or if the issue CAME TO A HEAD, we would call an interim meeting. He was happy with this approach. I would be grateful if Mr. Maslin could, in discussion with CVL and veterinary colleagues draft such a note, which will presumably very largely follow what Mr. Bradley's briefing paper has already said, taking account of DOH comments, We can then clear a final version with DOH before circulating it to Committee members.
http://web.archive.org/web/20030714222309/www.bseinquiry.gov.uk/files/yb/1992/10/29005001.pdf
IN CONFIDENCE
This is a highly competitive field and it really will be a pity if we allow many of the key findings to be published by overseas groups while we are unable to pursue our research findings because of this disagreement, which I hope we can make every effort to solve.
http://web.archive.org/web/20030714222309/www.bseinquiry.gov.uk/files/yb/1992/10/26002001.pdf
COLLINGE THREATENS TO GO TO MEDIA
http://web.archive.org/web/20030714222309/www.bseinquiry.gov.uk/files/yb/1992/12/16005001.pdf
Saturday, June 13, 2009
Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States 2003 revisited 2009
http://cjdusa.blogspot.com/2009/06/monitoring-occurrence-of-emerging-forms.html
Tuesday, August 11, 2009
Characteristics of Established and Proposed Sporadic Creutzfeldt-Jakob Disease Variants
Brian S. Appleby, MD; Kristin K. Appleby, MD; Barbara J. Crain, MD, PhD; Chiadi U. Onyike, MD, MHS; Mitchell T. Wallin, MD, MPH; Peter V. Rabins, MD, MPH
Background: The classic Creutzfeldt-Jakob disease (CJD), Heidenhain, and Oppenheimer-Brownell variants are sporadic CJD (sCJD) phenotypes frequently described in the literature, but many cases present with neuropsychiatric symptoms, suggesting that there may be additional sCJD phenotypes.
Objective: To characterize clinical, diagnostic, and molecular features of 5 sCJD variants.
Design: Retrospective analysis.
Setting: The Johns Hopkins and Veterans Administration health care systems.
Participants: Eighty-eight patients with definite or probable sCJD.
Main Outcome Measures: Differences in age at onset, illness progression, diagnostic test results, and molecular subtype.
Results: The age at onset differed among sCJD variants (P=.03); the affective variant had the youngest mean age at onset (59.7 years). Survival time (P.001) and the time to clinical presentation (P=.003) differed among groups. Patients with the classic CJD phenotype had the shortest median survival time from symptom onset (66 days) and those who met criteria for the affective sCJD variant had the longest (421 days) and presented to clinicians significantly later (median time from onset to presentation, 92 days; P=.004). Cerebrospinal fluid analyses were positive for 14-3-3 protein in all of the affective variants, regardless of illness duration. Periodic sharp-wave complexes were not detected on any of the electroencephalography tracings in the Oppenheimer-Brownell group; basal ganglia hyperintensity was not detected on brain magnetic resonance imaging in this group either. All of the Heidenhain variants were of the methionine/ methionine type 1 molecular subtype.
Conclusions: The classic CJD phenotype and the Heidenhain, Oppenheimer-Brownell, cognitive, and affective sCJD variants differ by age at disease onset, survival time, and diagnostic test results. Characteristics of these 5 phenotypes are provided to facilitate further clinicopathologic investigation that may lead to more reliable and timely diagnoses of sCJD.
Arch Neurol. 2009;66(2):208-215
snip...
COMMENT
snip...see full text ;
http://creutzfeldt-jakob-disease.blogspot.com/2009/08/characteristics-of-established-and.html
Thursday, November 05, 2009
Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification
http://creutzfeldt-jakob-disease.blogspot.com/2009/11/incidence-and-spectrum-of-sporadic.html
Thursday, November 12, 2009
BSE FEED RECALL Misbranding of product by partial label removal to hide original source of materials 2009
http://madcowfeed.blogspot.com/2009/11/bse-feed-recall-misbranding-of-product.html
Friday, September 4, 2009
FOIA REQUEST ON FEED RECALL PRODUCT 429,128 lbs. feed for ruminant animals may have been contaminated with prohibited material Recall # V-258-2009
http://madcowfeed.blogspot.com/2009/09/foia-request-on-feed-recall-product.html
Saturday, August 29, 2009
FOIA REQUEST FEED RECALL 2009 Product may have contained prohibited materials Bulk Whole Barley, Recall # V-256-2009
http://madcowfeed.blogspot.com/2009/08/foia-request-feed-recall-2009-product.html
CONFIRMED BSE RELATED FEED BAN RECALL USA VIA FOIA 2009...TSS
----- Original Message ----- From: "Terry S. Singeltary Sr."To: Sent: Thursday, November 05, 2009 9:25 PM Subject: [BSE-L] re-FOIA REQUEST ON FEED RECALL PRODUCT contaminated with prohibited material Recall # V-258-2009 and Recall # V-256-2009
http://madcowfeed.blogspot.com/2009/11/re-foia-request-on-feed-recall-product.html
TSS
To the hard working employees of USDA and their untiring efforts to protect our food supply
Little is known and much has been written Of the deadly disease with which some have been smitten It is certainly true there have been but a few But down on the farm there is cause for alarm
It causes great stress to the CNS T’is a strain on the brain as we shall soon see The causative agent is anyone’s guess A transmissible spongiform encephalopathy
Sheep Scrapie somehow in the UK to Mad Cow Here in the US it is anyone’s guess It’s not perfectly clear how our elk and our deer Both the tame and the free got CWD
To the best of our knowledge out west at a college Where they happened to keep some deer penned with sheep They didn't know why the deer started to die Because they did not know they let the rest go
Now from Washington state comes news that’s not great Ann Veneman tells us how they have found a MAD COW The Federal Vet said she’s a “down cow” you bet But Dave Louthan the talker say’s she was a “walker”
She was grist for the mill, she went regular kill So they started to track when the test did come back But that was 2 weeks later and people had ate her The meat was consumed and the recall was doomed
Now we must remember this occurred in December Ann and Bush have no fears, they’ll have beef for New Years
addendum
There was no proper test In a plant way out west The old cow was unwell, she staggered and fell “We don’t want her” said Ronald, “she’s not for McDonald” The vet made a call and was told not to test after all
Headquarters told Lonestar “we cant send a car” “It’s too long a trip, you don’t know how to ship” No brainstem will you tender, just send her to render We don’t want a section - wait till after election
by the Bard of Bismarck, the Old Curmudgeon Earl Fairbanks DVM USDA Ret.
addendum II 2008. ...TSS
To the hard working employees of USDA and their untiring efforts to protect our childrens food supply
and who gives a fickle, if the last two were atypical, more virulent to animals and man, we'll grind em and crush em, even the stumbling and staggering ones.
those diseased, those sick, the ones injured, be quick. another shot of antibiotics or hormones, it matters not. it's profit, it's profit, look at all we got $$$
those downers, those downers, the ones that cannot stand, oh where, oh where, can they go? with the fork lift at hand, they chain em and stand, and drag them to where know one goes. we'll shock em, and poke em, even waterboard em, and then off to the children they go.
in a long case study, we'll wait and wonder, watching for every little twitch, which one of these children, will be the first to succumb, to the monster we know as the mad cow prion.
100% fatal, for those that go clinical, with no therapy there is. you wait and wonder, as the mind goes, wondering how many others might have been exposed. there is no test, without any guess, you don't care to know.
and for those that lay claim, to no one is sick, beware, beware, for these are the facts. the mad cow prion, can lay dormant before it attacks. for years and years, and even decades to come, your children, will incubate, before they might succumb.
while Washington flounders, the mad cows still wanders, the downers they continue to go, to the cattle feed, to the childrens food and on, nobody knows. from waxman, to durbin, to bush, to leahy, the lies, and promises abound, they just seem to go round and round $$$
it's a sad, sad mess i have come to know, but the downers, all the downers, off to the incinerator they must go. ...TSS 2008
Thursday, May 13, 2004
Food Safety
Failure To Test Staggering Cow May Reflect Wider Problems
Rep. Waxman raises concerns that the recent failure of USDA to test an impaired cow for BSE may not be an isolated incident, citing the failure of USDA to monitor whether cows condemned for central nervous system symptoms are actually tested for mad cow disease.
http://reform.democrats.house.gov/documents/20040607142914-86912.pdf
http://oversight.house.gov/documents/20040607142914-86912.pdf
Statement Of Senator Patrick Leahy Senate Agriculture Committee Hearing On Mad Cow Disease January 27, 2004
For years I have joined with Senator Akaka in attempting to restrict downers from the human food supply, thus I am pleased the Department reversed course and will now implement the Downed Animal Protection Act that was contained in the 2002 Farm Bill for cattle.
http://leahy.senate.gov/press/200401/012704.html
CALIFORNIA STATE CAUCUS
Briefing Report: Mad Cow Disease
2/11/2004 - For Immediate Release
Recent Actions
On December 30, 2003, United States Agriculture Secretary Ann Veneman announced additional safeguards to bolster the U.S. protection system against BSE and to further protect public health. Downer cattle and specified risk material and tissues will immediately be banned from the human food chain. If people do not eat these dangerous parts of the cow, their risk of acquiring BSE is severely reduced.
http://republican.sen.ca.gov/opeds/99/oped2091_print.asp
2008
USDA CERTIFIED NON-AMBULATORY DOWNER COW SCHOOL LUNCH PROGRAM
http://downercattle.blogspot.com/2008/02/beef-recall-nationwide-school-lunch.html
Specified Risk Material SRM
http://madcowspontaneousnot.blogspot.com/2008/02/specified-risk-materials-srm.html
Subject: [Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk Materials for Human Food and Requirements for the Disposition of Non-Ambulatory Disabled Cattle
Greetings FSIS,
I would kindly like to submit the following to [Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk Materials for Human Food and Requirements for the Disposition of Non-Ambulatory Disabled Cattle
THE BSE/TSE SUB CLINICAL
Non-Ambulatory Disabled Cattle Broken bones and such may be the first signs of a sub clinical BSE/TSE Non-Ambulatory Disabled Cattle ;
SUB CLINICAL PRION INFECTION MRC-43-00 Issued: Monday, 28 August 2000
NEW EVIDENCE OF SUB-CLINICAL PRION INFECTION: IMPORTANT RESEARCH FINDINGS RELEVANT TO CJD AND BSE
A team of researchers led by Professor John Collinge at the Medical Research Council Prion Unit1 report today in the Proceedings of the National Academy of Sciences, on new evidence for the existence of a "sub-clinical" form of BSE in mice which was unknown until now. The scientists took a closer look at what is known as the "species barrier" - the main protective factor which
limits the ability of prions2 to jump from one species to infect another. They found the mice had a "sub-clinical" form of disease where they carried high levels of infectivity but did not develop the clinical disease during their normal lifespan. The idea that individuals can carry a disease and show no clinical symptoms is not new. It is commonly seen in conventional infectious diseases. Researchers tried to infect laboratory mice with hamster prions3 called Sc237 and found that the mice showed no apparent signs of disease. However, on closer inspection they found that the mice had high levels of mouse prions in their brains. This was surprising because it has always been assumed that hamster prions could not cause the disease in mice, even when injected directly into the brain. In addition the researchers showed that this new sub-clinical infection could be easily passed on when injected into healthy mice and hamsters. The height of the species barrier varies widely between different combinations of animals and also varies with the type or strain of prions. While some barriers are quite small (for instance BSE easily infects mice), other combinations of strain and species show a seemingly impenetrable barrier. Traditionally, the particular barrier studied here was assumed to be robust. Professor John Collinge said: "These results have a number of important implications. They suggest that we should re-think how we measure species barriers in the laboratory, and that we should not assume that just because one species appears resistant to a strain of prions they have been exposed to, that they do not silently carry the infection.
This research raises the possibility, which has been mentioned before, that apparently healthy cattle could harbour, but never show signs of, BSE. "This is a timely and unexpected result, increasing what we know about prion disease. These new findings have important implications for those researching prion disease, those responsible for preventing infected material getting into the food chain and for those considering how best to safeguard health and reduce the risk that theoretically, prion disease could be contracted through medical and surgical procedures."
ISSUED FRIDAY 25 AUGUST UNDER EMBARGO. PLEASE NOTE THAT THE EMBARGO IS SET BY THE JOURNAL.
http://www.mrc.ac.uk/index/public_interest/public-press_office/public-press_releases_2000/public-mrc-43-00.htm
SNIP...
https://web01.aphis.usda.gov/regpublic.nsf/0/eff9eff1f7c5cf2b87256ecf000df08d?OpenDocument
PNAS August 29, 2000 vol. 97 no. 18 10248-10253 Neurobiology
Species-barrier-independent prion replication in apparentlyresistant species
Andrew F. Hill*, Susan Joiner*, Jackie Linehan*, Melanie Desbruslais*, Peter L. Lantos , and John Collinge*,
SEE FULL TEXT 17 pages ;
http://www.fsis.usda.gov/OPPDE/Comments/03-025IFA/03-025IFA-2.pdf
Thursday, February 21, 2008
TRANSCRIPT: Technical Briefing - Hallmark/Westland Meat Packing Company - (02/21/08)
Release No. 0054.08
http://downercattle.blogspot.com/
http://downercattle.blogspot.com/2008/02/transcript-technical-briefing.html
Sunday, February 17, 2008
Release No. 0046.08 Statement by Secretary of Agriculture Ed Schafer Regarding Hallmark/Westland Meat Packing Company Two Year Product Recall
Release No. 0046.08
Contact: USDA Press Office (202) 720-4623
http://cjdmadcowbaseoct2007.blogspot.com/2008/02/release-no-004608-statement-by.html
Geographical BSE Risk (GBR) assessments covering 2000-2006
Date : 01.08.2006
http://www.efsa.europa.eu/EFSA/Scientific_Document/GBR_assessments_table_Overview_assessed_countries_2002-2006.pdf
In this context, a word is in order about the US testing program. After the discovery of the first (imported) cow in 2003, the magnitude of testing was much increased, reaching a level of >400,000 tests in 2005 (Figure 4). Neither of the 2 more recently indigenously infected older animals with nonspecific clinical features would have been detected without such testing, and neither would have been identified as atypical without confirmatory Western blots. Despite these facts, surveillance has now been decimated to 40,000 annual tests (USDA news release no. 0255.06, July 20, 2006) and invites the accusation that the United States will never know the true status of its involvement with BSE.
http://www.cdc.gov/ncidod/EID/vol12no12/06-0965.htm
PAUL BROWN COMMENT TO ME ON THIS ISSUE
Tuesday, September 12, 2006 11:10 AM
"Actually, Terry, I have been critical of the USDA handling of the mad cow issue for some years, and with Linda Detwiler and others sent lengthy detailed critiques and recommendations to both the USDA and the Canadian Food Agency."
http://lists.iatp.org/listarchive/archive.cfm?listID=147&startrow=1081
BEEF RECALL - USA (05) ********************** A ProMED-mail post
ProMED-mail is a program of the International Society for Infectious Diseases
http://www.promedmail.org/pls/otn/f?p=2400:1001:3581618507331539::NO::F2400_P1001_BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,71607
MAD COW TESTING USA
http://madcowtesting.blogspot.com/
Wednesday, February 27, 2008 BEEF RECALL NATIONWIDE - SCHOOL LUNCH PROGRAM UPDATE
http://downercattle.blogspot.com/2008/02/beef-recall-nationwide-school-lunch.html
CJD QUESTIONNAIRE
http://cjdquestionnaire.blogspot.com/
Specified Risk Material SRM
http://madcowspontaneousnot.blogspot.com/2008/02/specified-risk-materials-srm.html
Beef - Westland/Hallmark Recall OF BEEF WITH DEADSTOCK DOWNER COWS, THE MOST HIGH RISK CATTLE FOR BSE/TSE AKA MAD COW DISEASE
Additional Products Listing 5-20-08
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
TOTAL DISTRIBUTION LIST
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20All%20Dist042008.pdf
ADDITIONAL PRODUCTS CONTAINING RECALLED BEEF
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
SEE FULL LIST OF ALL RECALLED SUSPECT DEAD STOCK DOWNER COW PRODUCTS HERE ;
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
Beef - Westland/Hallmark Recall OF BEEF WITH DEADSTOCK DOWNER COWS, THE MOST HIGH RISK CATTLE FOR BSE/TSE AKA MAD COW DISEASE
Additional Products Listing 5-20-08
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
TOTAL DISTRIBUTION LIST
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20All%20Dist042008.pdf
ADDITIONAL PRODUCTS CONTAINING RECALLED BEEF
http://www.cdph.ca.gov/pubsforms/Documents/fdb%20eru%20Hmrk%20Addl%20Prod052008.pdf
SEE FULL LIST OF ALL RECALLED SUSPECT DEAD STOCK DOWNER COW PRODUCTS HERE ;
http://www.cdph.ca.gov/HEALTHINFO/Pages/FDB%20Beef-WestlandHallmarkRecall.aspx
>>>In the papers, the government alleges the meatpacking plant slaughtered and processed downer cows for nearly four years — from January 2004 to September 2007 — <<<
>95%) downer or dead dairy cattle and a few horses. Sheep had never been fed.
PLEASE SEE ;
We believe that these findings may indicate the presence of a previously unrecognized scrapie-like disease in cattle and wish to alert dairy practitioners to this possibility.
snip...
PROCEEDINGS OF THE SEVENTH ANNUAL WESTERN CONFERENCE FOR FOOD ANIMAL VETERINARY MEDICINE, University of Arizona, March 17-19, 1986
http://web.archive.org/web/20030331063559/http://www.bseinquiry.gov.uk/files/mb/m09a/tab01.pdf
http://web.archive.org/web/20030516051623/http://www.bseinquiry.gov.uk/files/mb/m09/tab05.pdf
IN CONFIDENCE
PERCEPTIONS OF UNCONVENTIONAL SLOW VIRUS DISEASES OF ANIMALS IN THE USA
http://collections.europarchive.org/tna/20080102193705/http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf
Wednesday, August 20, 2008
Bovine Spongiform Encephalopathy Mad Cow Disease typical and atypical strains, was there a cover-up ? August 20, 2008
snip...
another question, just how long have these atypical BSE TSEs been around in the bovine ???
let's look at another case of atypical BSE in Germany way back in 1992 ;
Subject: atypical BSE reported in 1992 and conviently slaughterd and incinerated and then swept under rug for about 12 years Date: April 26, 2007 at 1:08 pm PST 1992
NEW BRAIN DISORDER
3. WHAT ABOUT REPORTS OF NEW FORM OF BSE?
THE VETERINARY RECORD HAS PUBLISHED AN ARTICLE ON A NEW BRAIN DISORDER OF CATTLE DISCOVERED THROUGH OUR CONTROL MEASURES FOR BSE. ALTHOUGH IT PRESENTS SIMILAR CLINICAL SIGNS TO BSE THERE ARE MAJOR DIFFERENCES IN THE HISTOPATHOLOGY AND INCUBATION PERIODS BETWEEN THE TWO. MUST EMPHASISE THAT THIS IS NOT BSE.
4. IS THIS NEW BRAIN DISORDER A THREAT?
WE DO NOT EVEN KNOW WHETHER THE AGENT OF THIS DISEASE IS TRANSMISSIBLE. IN ANY CASE, CASES SO FAR IDENTIFIED HAD SHOWN SIMILAR SYMPTOMS TO THOSE OF BSE, AND THEREFORE HAVE BEEN SLAUGHTERED AND INCINERATED, SO THAT IF A TRANSMISSIBLE AGENT WERE INVOLVED IT WOULD HAVE BEEN ELIMINATED. .......
http://web.archive.org/web/20030714222309/www.bseinquiry.gov.uk/files/yb/1992/10/26001001.pdf
2. The Collinge/Will dispute appears to rumble on. Dr. Collinge had told Dr. Tyrrell that Dr. Will's response to his criticism about sharing material had been ''quite unacceptable'' (in spite of it's apparently conciliatory tone). Apparently Professor Allen was now going to try and arrange a meeting to resolve the dispute. No action here for MAFF, although Mr. Murray may be interested.
3. Dr. Tyrrell regretted that the Committee had not seen the article on BBD. However he felt that for the time being NO specific action was called for. The most important need was to consider the possibility that the condition might be transmissible. As we have discussed, I suggested that we might circulate a paper to the members of the committee giving our appreciation of this condition (and perhaps of other non-BSE neurological conditions that had been identified in negative cases) and of any necessary follow up action. IF any Committee member felt strongly about this, or if the issue CAME TO A HEAD, we would call an interim meeting. He was happy with this approach. I would be grateful if Mr. Maslin could, in discussion with CVL and veterinary colleagues draft such a note, which will presumably very largely follow what Mr. Bradley's briefing paper has already said, taking account of DOH comments, We can then clear a final version with DOH before circulating it to Committee members.
http://web.archive.org/web/20030714222309/www.bseinquiry.gov.uk/files/yb/1992/10/29005001.pdf
IN CONFIDENCE
This is a highly competitive field and it really will be a pity if we allow many of the key findings to be published by overseas groups while we are unable to pursue our research findings because of this disagreement, which I hope we can make every effort to solve.
http://web.archive.org/web/20030714222309/www.bseinquiry.gov.uk/files/yb/1992/10/26002001.pdf
COLLINGE THREATENS TO GO TO MEDIA
http://web.archive.org/web/20030714222309/www.bseinquiry.gov.uk/files/yb/1992/12/16005001.pdf
Saturday, June 13, 2009
Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States 2003 revisited 2009
http://cjdusa.blogspot.com/2009/06/monitoring-occurrence-of-emerging-forms.html
Tuesday, August 11, 2009
Characteristics of Established and Proposed Sporadic Creutzfeldt-Jakob Disease Variants
Brian S. Appleby, MD; Kristin K. Appleby, MD; Barbara J. Crain, MD, PhD; Chiadi U. Onyike, MD, MHS; Mitchell T. Wallin, MD, MPH; Peter V. Rabins, MD, MPH
Background: The classic Creutzfeldt-Jakob disease (CJD), Heidenhain, and Oppenheimer-Brownell variants are sporadic CJD (sCJD) phenotypes frequently described in the literature, but many cases present with neuropsychiatric symptoms, suggesting that there may be additional sCJD phenotypes.
Objective: To characterize clinical, diagnostic, and molecular features of 5 sCJD variants.
Design: Retrospective analysis.
Setting: The Johns Hopkins and Veterans Administration health care systems.
Participants: Eighty-eight patients with definite or probable sCJD.
Main Outcome Measures: Differences in age at onset, illness progression, diagnostic test results, and molecular subtype.
Results: The age at onset differed among sCJD variants (P=.03); the affective variant had the youngest mean age at onset (59.7 years). Survival time (P.001) and the time to clinical presentation (P=.003) differed among groups. Patients with the classic CJD phenotype had the shortest median survival time from symptom onset (66 days) and those who met criteria for the affective sCJD variant had the longest (421 days) and presented to clinicians significantly later (median time from onset to presentation, 92 days; P=.004). Cerebrospinal fluid analyses were positive for 14-3-3 protein in all of the affective variants, regardless of illness duration. Periodic sharp-wave complexes were not detected on any of the electroencephalography tracings in the Oppenheimer-Brownell group; basal ganglia hyperintensity was not detected on brain magnetic resonance imaging in this group either. All of the Heidenhain variants were of the methionine/ methionine type 1 molecular subtype.
Conclusions: The classic CJD phenotype and the Heidenhain, Oppenheimer-Brownell, cognitive, and affective sCJD variants differ by age at disease onset, survival time, and diagnostic test results. Characteristics of these 5 phenotypes are provided to facilitate further clinicopathologic investigation that may lead to more reliable and timely diagnoses of sCJD.
Arch Neurol. 2009;66(2):208-215
snip...
COMMENT
snip...see full text ;
http://creutzfeldt-jakob-disease.blogspot.com/2009/08/characteristics-of-established-and.html
Thursday, November 05, 2009
Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification
http://creutzfeldt-jakob-disease.blogspot.com/2009/11/incidence-and-spectrum-of-sporadic.html
Thursday, November 12, 2009
BSE FEED RECALL Misbranding of product by partial label removal to hide original source of materials 2009
http://madcowfeed.blogspot.com/2009/11/bse-feed-recall-misbranding-of-product.html
Friday, September 4, 2009
FOIA REQUEST ON FEED RECALL PRODUCT 429,128 lbs. feed for ruminant animals may have been contaminated with prohibited material Recall # V-258-2009
http://madcowfeed.blogspot.com/2009/09/foia-request-on-feed-recall-product.html
Saturday, August 29, 2009
FOIA REQUEST FEED RECALL 2009 Product may have contained prohibited materials Bulk Whole Barley, Recall # V-256-2009
http://madcowfeed.blogspot.com/2009/08/foia-request-feed-recall-2009-product.html
CONFIRMED BSE RELATED FEED BAN RECALL USA VIA FOIA 2009...TSS
----- Original Message ----- From: "Terry S. Singeltary Sr."
http://madcowfeed.blogspot.com/2009/11/re-foia-request-on-feed-recall-product.html
TSS
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